感染指标联合检测对新生儿败血症早期诊断的意义  

Combined detection of infection markers in early diagnosis of neonatal sepsis

作　　者：胡倩[1] 杜玮[1] 刘晓红[1] 

机构地区：[1]深圳市儿童医院新生儿科,广东深圳518000

出　　处：《西北国防医学杂志》2014年第1期46-48,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:观察新生儿败血症患儿CD64、PCT及hs-CRP的变化并评价三者联合检测的临床意义。方法:对新生儿败血症组100例及同期入院的非感染对照组100例分别检测CD64、PCT及hs-CRP三项指标,1周后选败血症组中临床好转患儿50名作为恢复组,复查三项指标。CD64,PCT和hs-CRP分别用流式细胞技术、电化学发光免疫测定法、免疫比浊法进行检测。结果:新生儿败血症组三项指标均明显高于非感染对照组,恢复组三项指标均明显下降,具有统计学差异(P<0.05)。与单项检测相比,联合检测的敏感性、特异性、阳性预测值、阴性预测值及约登指数均明显提高。结论:联合检测三项指标的水平及变化,有助于新生儿败血症的临床早期诊断及疗效评价。Objective： To investigate the application value of leukocyte surface antigens CD64, serum procalcitonin （PCT） and hs--CRP in the early diagnosis of neonatal sepsis. Methods： A total of 200 patients were divided into sepsis group （n= 100） and non--infection group （n=100）, and the leukocyte surface antigens CD64, PCT and hs--CRP were measured before the use of antibiotics. The three markers were measured again 7 days after treatment for 50 sepsis patients in effective remedy as recovery group. The CD64, PCT and hs--CRP were detected by FCM, ECLIA and nephelometry, respectively. Results： The levels of CD64, PCT and hs--CRP in the sepsis group were higher than those in non--infection group （P〈0.05）, and were decreased significantly in the recovery group compared with the sepsis group （P〈 0.05）. Compared with any single measurement, the sensitivity, specificity, positive predict value （PPV）, negative predict value （NPV） and Youden index of combined detection were apparently increased. Conclu- sion： The combined detection of CD64, PCT and hs--CRP may be useful for the early diagnosis and curative effect evaluation of neonatal sepsis.

关 键 词：新生儿败血症 中性粒细胞CD64 降钙素原 

分 类 号：R722.131[医药卫生—儿科]