新疆维吾尔族女性脂质代谢紊乱与细胞因子信号转导抑制因子3基因变异相关  

Relationship between Female Dyslipidemia and Polymorphism of Suppressor of Cytokine Signaling-3 in Xinjiang Uygur Population

作　　者：孟静[1] 李南方[2] 姚晓光[2] 邵亮[2] 周玲[2] 艾力根.阿布都热依木 张晶晶[2] 

机构地区：[1]石河子大学医学院临床医学系,新疆石河子832000 [2]新疆维吾尔自治区人民医院高血压中心新疆高血压研究所,乌鲁木齐830001

出　　处：《中国医学科学院学报》2014年第1期5-11,共7页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(31060157);新疆维吾尔自治区重点实验室开放性课题(XJYS0906-2014-01);新疆维吾尔自治区人民医院院内项目(20130105)~~

摘　　要：目的 研究新疆维吾尔族女性脂质代谢紊乱与细胞因子信号转导抑制因子3（SOCS-3）基因变异的相关性.方法以1379 名新疆维吾尔族人为研究对象,选择rs12953258、rs4969168和rs9914220 3个代表性位点进行基因型鉴定后分析.结果 3个位点中,仅发现维吾尔族女性的 rs12953258位点在脂质代谢紊乱组及脂质代谢正常组中基因型频率分布差异有统计学意义（P=0.032）,在高密度脂蛋白胆固醇（HDL-C）异常组与正常组中基因型频率分布差异有统计学意义（P=0.029）.Logistic回归分析结果显示,rs12953258位点AA基因型可能是新疆维吾尔族女性脂质代谢紊乱的危险因素 [CC比AA：OR=3.271,95%CI（1.092～9.797）,P=0.034],AA基因型可能与HDL-C降低和三酰甘油升高有关,AA基因型合并体重指数（BMI）异常的维吾尔族女性更易患脂质代谢紊乱性疾病.结论 SOCS-3基因变异可能与新疆维吾尔族女性脂质代谢紊乱相关,携带AA基因型且BMI异常人群脂质代谢紊乱的患病率明显增加.Objective To explore whether the polymorphism of suppressor of cytokine signaling-3 （SOCS-3） and dyslipidemia are correlated in Uygnr females. Methods A total of 1379 Uygur females from Xin- jiang Uygur Autonomous Region were enrolled in this study. Three single nucleotide polymorphisms （SNPs）, namely rs12953258, rs4969168, and rs9914220, were analyzed after being genotyped. Results Of these three SNPs, the frequency distribution of rs12953258 sites was found to be significantly different between dyslipidemia group and normal group （P = 0. 032） . The frequency distribution of rs12953258 sites between the high-density lip- oprotein-cholesterol （HDL-C） abnormal group and normal group also showed significant difference （P = 0. 029）. Logistic regression analysis showed that the genotype AA of rs12953258 was a risk factor for dyslipidemia among the Uygurfemales [CC vs. AA： OR =3.271, 95% CI （1.092 -9.797）, P =0.034]. The genotype AA of rs12953258 might be related to the decreased high HDL-C and increased trigleceride, whereas the genotype AA coupled with abnormal body mass index （BMI） were more likely to be linked with the higher prevalence of dyslipi- demia in Uygur females. Conclusions The polymorphism of SOCS-3 is correlated to the dyslipidemia in Uygur females in Xinjiang. Carriers of Genotype AA of rs12953258 coupled with abnormal BMI are more susceptible to dyslipidemia.

关 键 词：细胞因子信号转导抑制因子3基因 脂质代谢紊乱 瘦素 

分 类 号：R589.2[医药卫生—内分泌]