精子发生过程中的组蛋白变化与雄性不育  

Histone Modifications during Spermatogenesis and Male Infertility

作　　者：潘晓燕[1] 李质馨[1] 王正朝[2] 王雪楠[3] 黄冰洋[1] 窦肇华[1] 孙艳美[4] 

机构地区：[1]吉林医药学院组织学与胚胎学教研室,吉林吉林132013 [2]福建师范大学生命科学学院发育与神经生物学重点实验室,福州350007 [3]济宁医学院附属医院生殖医学中心,山东济宁272029 [4]吉林医药学院检验学院,吉林吉林132013

出　　处：《中国医学科学院学报》2014年第1期108-113,共6页Acta Academiae Medicinae Sinicae

基　　金：吉林省中医药管理局中医药科技项目(2012-165);吉林省科技发展计划项目(201201077;20140204033YY);吉林市科技发展计划资助项目(2013625023);山东省高等学校科技计划项目(J13LL04);吉林省教育厅"十二五"科学技术研究项目[吉教科合字(2014)第366号]~~

摘　　要：男性不育的许多病理现象与生精细胞的表观遗传改变关系密切。表观遗传在精子发生过程中调控着生精细胞的有丝分裂、减数分裂和精子形成过程,其中,作为表观遗传的一个重要研究内容——组蛋白,在精子发生过程中会发生多位点和多种形式的氨基酸残基修饰,不同的修饰方式在精子发生的不同阶段精确地调控着生殖细胞的发育过程,且在精子形成阶段发生鱼精蛋白和组蛋白的替换。此外,在精子发生过程中,组蛋白修饰的异常改变还可能会损伤精子的发育过程,导致雄性不育。本文总结了精子发生过程中组蛋白修饰的变化、对生殖细胞发育的调控作用,以及组蛋白的异常改变与雄性不育的关系。Many pathological phenomena of male infertility are related to epigenetie changes in male germ cells. Epigenetic regulation during spermatogenesis plays an important role in mitotic/meiotic divisions and spermiogenesis. The histones have various post-translational modifications on different amino acid residues during spermatogenesis. These modifications are crucial to the precise regulation of spermatogenesis. Moreover, the his- tone-to-protamine transition will occur during spermiogenesis. Many studies have also found that abnormal changes of histone modifications during spermatogenesis may damage the sperm development, leading to male sterili- ty. This article reviews the changes of histone modifications during spermatogenesis, the regulation of the develop- ment of male germ cells, and the relationship between histone abnormalities and male sterility.

关 键 词：精子发生 组蛋白修饰 鱼精蛋白 雄性不育 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]