哮喘患者必可酮治疗前后引痰液中细胞因子水平及意义  

Induced sputum lends a hand in treatment for asthmatics patients with Bicotide

作　　者：樊卫文[1] 孙滨[1] 吴昌归[1] 米建新[1] 

机构地区：[1]第四军医大学西京医院呼吸内科,陕西西安710033

出　　处：《第四军医大学学报》2001年第3期253-255,共3页Journal of the Fourth Military Medical University

基　　金：全军医药卫生科研基金资助课题 !(96M14 1)

摘　　要：目的　探讨哮喘患者发作期及激素治疗前后引痰液中炎症介质 IL- 8,TNF- α和 ECP(嗜酸细胞阳离子蛋白 )含量对判定哮喘气道炎症及疗效的意义 .方法　用高渗盐水雾化引痰、荧光免疫法及酶联免疫法检测发作期哮喘患者以及吸入必可酮 (二丙酸倍氯米松气雾剂 )治疗 4wk后引痰液中IL- 8,TNF- α和 ECP等水平 .结果　哮喘患者引痰液中 IL-8,TNF- α和 ECP等水平在必可酮治疗 4wk后较其发作期有显著下降 .结论　测定引痰液炎症介质 IL- 8,TNF-AIM To assess whether levels of IL 8, TNF α and ECP in the induced sputum reflect the level of the airway inflammation of bronchial asthma. METHODS Induced sputum was used by inhalation of hypertonic saline to analyse concentrations of eosinophil cationic protein (ECP), interleukin 8 (IL 8) and tumour necrosis factor α(TNF α) by radioimmunoassay (RIA) or enzyme linked immunosorbent assay (ELISA). RESULTS Levels of TNF α, ECP and IL 8 in patients with inhalation of Bicotide for 4 weeks were less than those with acute attacks of asthma. CONCLUSION Analysing the induced sputum can be used to assess the airway inflammation and the effects of treatment.

关 键 词：哮喘 气道炎症 痰 白细胞介素8 肿瘤坏死因子-α 必可酮 治疗 

分 类 号：R562.25[医药卫生—呼吸系统]