维药阿育魏实水提物急性毒性及抗炎作用研究  

Studies on Acute Toxicity and Anti-inflammation of the Trachyspermum ammi(L.)Sprague

作　　者：帕丽达.阿不力孜 丁燕楠 丛媛媛[1] 米仁沙.牙库甫 麦合木提江.库迪热提 

机构地区：[1]新疆医科大学药学院,新疆乌鲁木齐830011

出　　处：《亚太传统医药》2014年第3期12-13,共2页Asia-Pacific Traditional Medicine

基　　金：新疆医科大学大学生创新实验计划项目(CX2013006)

摘　　要：目的:研究阿育魏实水提物的急性毒性及抗炎活性。方法:制备阿育魏实的水提组分(TaS),采用最大给药量法测定急性毒性实验;采用二甲苯致耳肿胀法建立炎症模型,考察其抗炎活性。结果:阿育魏实急性毒性试验测得小鼠灌胃最大耐受量为352g生药/kg,相当于人日用量的3 520多倍;抗炎试验表明阿育魏实高、低剂组均能显著抑制二甲苯所致小鼠耳肿胀。结论:阿育魏实水提物安全无毒,具有一定的抗炎活性。Objective ： To study the anti-inflammation effect and acute toxicity of the Trachyspermum ammi （L.） Sprague. Meth- ods ： The maximum administration dosage （MTD） of TaS was determined by ig intragastric administration with the maximum con- centration and the maximum amounts in mice and anti inflammatory model of mouse ear edema induced by xylene. Results： The MTD test showed that the MTD of TaS was 352g/kg ,equal to 3520 times of the normal human （50kg）. TaS could inhibit the mice ear edema induced by xyiene. Conclusion： TaS is safe in clinic use and has some certain effect on ant^inflammation.

关 键 词：阿育魏实 急性毒性 抗炎作用 

分 类 号：R285.5[医药卫生—中药学]