姜黄素激活Nrf2-ARE通路抑制镉肾毒性的研究进展  

Antagonism of curcumin on cadmium-induced nephrotoxicity by activating Nrf2-ARE pathway:a review of recent studies

作　　者：黎珊珊[1] 徐兆发[1] 

机构地区：[1]中国医科大学公共卫生学院环境卫生学教研室,辽宁沈阳110001

出　　处：《环境与健康杂志》2014年第1期90-93,共4页Journal of Environment and Health

摘　　要：长期暴露于镉可造成机体肾脏的慢性氧化损伤。姜黄素作为一种天然抗氧化物,能上调多种细胞核转录相关因子2(Nrf2)核转位,保护机体免受氧化应激的损伤。应用姜黄素激活Nrf2-抗氧化反应元件(ARE)信号通路、拮抗镉所致肾毒性可能为镉中毒的防治提供新的手段。该文就Nrf2信号通路在镉致肾脏损伤中的拮抗作用及姜黄素诱导Nrf2-ARE信号通路活化对机体的保护作用进行综述。Long term exposure to cadmium may lead to chronic renal injury. Curcumin can raise a variety of Nrf2 nuclear translocation and protect the body from oxidative stress damage. Curcumin can activate the Nrf2-ARE signaling pathway to protect against cadmium-induced nephrotoxicity which would provide a new method in preventing the cadmium poisoning. The present article discussed about the function of Nrf2 signaling pathway to protect against cadmium-induced nephrotoxicity and researched on curcumin-induced Nrf2-ARE signaling pathway effecting on the body＇s protective mechanism.

关 键 词：镉 肾毒性 氧化损伤 转录相关因子2-抗氧化反应元件信号通路 姜黄素 

分 类 号：R994.6[医药卫生—毒理学]