西咪替丁对过敏性紫癜NK细胞数量及其杀伤活性的影响  

The natural immunity changes in Henoch-Schonlein Purpura:before and after Cimetidine treatment

作　　者：赵刚[1] 符仁义[2] 杨崇礼[2] 罗春华[2] 

机构地区：[1]武警广东总队医院儿科,广州510507 [2]华西医科大学第二附属医院儿科

出　　处：《广州医药》2001年第1期14-15,共2页Guangzhou Medical Journal

摘　　要：目的 :测定西咪替丁对HSP患儿NK细胞数及杀伤活性的变化 ,探讨西咪替丁对天然免疫的调节作用。方法 :用流式细胞技术检测外周血NK细胞数 ,用LDH改良释放法测NK杀伤活性。结果 :在HSP患儿NK细胞数下降 ,杀伤活性降低。西咪替丁治疗后NK细胞杀伤活性增加 ,而数量无改变。结论 :西咪替丁能增加NK细胞的杀伤活性 ,而这种增强作用不是通过增加NK细胞数量 ,而是通过影响其周围微环境所致。The object of this study was to evaluate the effects of Cimetidine treatment to natural immunity in Henoch-Schonlein Purpura(HSP) The NK cell in peripheral blood were detected by double marker flow cytemeter(FCM) in addition, the cytotoxic activity of NK cell in peripheral blood were measured before and after Cimetidine Results: Compared with control group, the NK cell popular and cytotoxic activity of NK cell decreased in children with HSP during acute stage After 5 days Cimetidine treatment, cytotoxic activity of NK cell increased There were no significant differences in NK cell popular before and after treatment Conclusion: Cimetidine treatment can increase cytotoxic activity of NK cell This role of Cimetidine did not depends on increasing the NK cell, but also changed the microcircumstances of NK cell

关 键 词：西咪替丁 过敏性紫癜 自然杀伤细胞 杀伤活性 药物疗法 治疗 

分 类 号：R554.6[医药卫生—血液循环系统疾病]