Alzheimer病PET显像剂研究进展  

Research Progress of PET Traces for Alzheimer's Disease

作　　者：唐彩华[1,2] 胡孔珍[1] 唐刚华[1] 

机构地区：[1]中山大学附属第一医院核医学PET/CT中心,广东广州510080 [2]中山大学附属第五医院核医学科,广东珠海519000

出　　处：《同位素》2014年第1期55-63,共9页Journal of Isotopes

基　　金：国家自然科学基金面上项目(81371584);广东省科技计划项目(2010B031600054);广州市科技计划项目(2011J5200025)

摘　　要：Alzheimer病(AD)属于渐进性中枢神经系统退变性疾病,严重威胁老年人健康,其确诊主要依据死后病理检查。正电子发射断层(PET)显像技术在临床的广泛应用,为活体内早期无创性显像诊断AD提供有效途径,而PET显像的成功主要依赖于优良的正电子显像药物。近年来研制的应用于AD的PET显像剂大致有糖代谢类、β淀粉样蛋白(Aβ)结合类、tau蛋白结合类、神经递质及受体类、小胶质细胞活化的神经炎症类及细胞凋亡类。本文对近年来应用于AD的PET显像剂的研究进展进行了综述。central ne nosis is m Alzheimer＇s disease （AD） is unknown cause progre rvous system. It is a serious threat to the health of ainly based on pathological examination after death. ssive d the eld egenerative diseases of erly people. The diag- the wide application of positron emission tomography （PET） imaging in clinic, in vivo noninvasive imagin sis of AD at the early stage become possi labeled imaging agents. The PET imagin ferential diagnosis on AD include severa traces combined with amyloid p activation of microglia and PET PET tracers were reviewed that rote1 trac ble. PET imaging ly depends on g diagno positron g agents can be used in the early diagnosis and dif- 1 kinds. PET traces for glucose metabolic, PET nplaques, tau es for cell apo can be used in the protein, ptosis, T early dia neurotransmitter and receptor, he research progress of various gnosis and differential diagnosison AD in recent years.

关 键 词：ALZHEIMER病 放射性药物 正电子发射断层显像(PET) 

分 类 号：TL99[核科学技术—核技术及应用]