灯盏花素注射液对儿童病毒性心肌炎心率减速力的影响  

Effects of Dengzhanhuasu Injection on Deceleration Capacity of Heart Rate in Children with Viral Myocarditis

作　　者：顾坚[1] 鲍琼[1] 张仕超[1] 雷尚兵[1] 

机构地区：[1]湖北医药学院附属太和医院,湖北十堰442000

出　　处：《儿科药学杂志》2014年第3期23-25,共3页Journal of Pediatric Pharmacy

摘　　要：目的:探讨灯盏花素注射液对儿童病毒性心肌炎(VMC)心率减速力(DC)的影响。方法:将70例病毒性心肌炎患儿随机分为治疗组40例和对照组30例。治疗组给予灯盏花素注射液10 mg加入5%葡萄糖注射液250 mL静脉滴注;对照组给予辅酶A 100 U、ATP 40 mg加入5%葡萄糖注射液250 mL静脉滴注,疗程均为14 d。对所有患儿治疗前后进行24 h动态心电图监测,应用DC处理软件,离线计算DC值。结果:治疗组治疗后DC值明显升高,与治疗前比较差异有统计学意义(P<0.01);两组治疗后DC值及CK-MB值比较差异有统计学意义(P<0.01)。结论:病毒性心肌炎患儿伴有迷走神经功能受损,灯盏花素注射液可改善迷走神经功能,对心肌有保护作用。Objective： To study the effect of Dengzhanhuasu injection on deceleration capacity of heart rate in children with viral myocarditis. Methods： Seventy eases of children with viral myocarditis were divided into two groups. Dengzhanhuasu injection 10 mg/d was injected to the therapy group （n=40） for 14 days. The control group （n=30） was injected with Co A 100 U/d and ATP40 mg/d for 14 days. The DC in all patients before and after treatment was measured by using digitized 24 hours ECG recording. Results： After treatment the DC value was significantly riscd. The difference was statistically significant （P〈0.01）. The DC and CK-MB value in the two groups after treatment had a significant difference （P〈0.01 ）. Conclusions： It is suggested that vagus nerve damage is existed in children with viral myocarditis. Dengzhanhuasu injection can improve the vagus nerve function, and it has a protective effect on myocardia.

关 键 词：灯盏花素注射液 病毒性心肌炎 心率减速力 

分 类 号：R725.4[医药卫生—儿科]