盐酸雷莫司琼对外科手术后患者恶心呕吐等不良症状的预防体会  

Prophylactic effect research of Ramosetron hydrochloride for patients' nausea and vomitting and other symptoms

作　　者：李素平[1] 

机构地区：[1]郑州大学附属洛阳中心医院,洛阳471000

出　　处：《河南外科学杂志》2014年第1期19-22,共4页Henan Journal of Surgery

摘　　要：目的研究盐酸雷莫司琼(Ramosetron hydrochloride,RH)对外科手术后患者恶心呕吐等不良症状的预防效果。方法 2012-03—2013-03,选择外科实施开腹手术的胆道结石患者98例作研究对象。以数字法随机分成三组,即RH组(35例)和昂丹司琼组(32例),以及对照组(31例)。RH组在麻醉诱导之前的5 min静注0.3 mg RH。昂丹司琼组静注4 mg昂丹司琼。对照组单纯予以10 ml生理盐水。对比各组患者不同时间MAP及HR水平,术后恶心和呕吐分级情况以及PONV总发生率,以及不良反应情况。结果 RH组与昂丹司琼组及对照组在不同时间的MAP及HR水平方面对比,差异均无统计学意义(均P<0.05)。RH组的PONV总发生率为5.71%(2/35),显著低于对照组的38.71%(12/31),差异有统计学意义(x2=10.709,P=0.001)。但与昂丹司琼组的9.38%(3/32)相比,差异无统计学意义(x2=0.324,P=0.569)。各组间不良反应相比,差异均无统计学意义(均P>0.05)。结论以RH药物对外科手术后的患者实施预防性治疗,可有效减少不良症状,降低PONV发生率,疗效显著,值得临床推荐。Objective To study prophylactic effect research of Ramosetron hydrochloride for patients＇ nausea and vomitting and other symptoms.Methods From March 2012 to March 2013,chose 98 cases surgical laparotomy in patients with biliary stones in our hospital for the study.Digital randomly divided into three groups,namely RH group （35 cases） and ondansetron group （32 cases）,and the control group （31 cases）.RH group was treated intravenously with 0.3mgRH 5min before the induction of anesthesia.Ondansetron group was treated intravenously with 4mg ondansetron.Control group was treated with 10ml saline.Comparison of patients in each group levels of MAP and HR at different time,classification of postoperative nausea and vomiting as well as the overall incidence of PONV and adverse reactions.Results RH group and ondansetron group and the control group in comparison of MAP and HR levels at different times,the difference was not statistically significant （P〈0.05）.The overall incidence of PONV in RH group was 5.71% （2/35 ） ,significantly lower than 38.71% in the control group （12/31）,the difference was statistically significant （P〈0.05）.However,compared with ondansetron group of 9.38% （3/32）,the difference was not statistically significant （P〈0.05）.Adverse reactions was compared among the groups,the difference was not statistically significant （P〉 0.05）.Conclusion RH drugs using after surgery the patient of preventive treatment can effectively reduce the adverse symptoms and reduce the incidence of PONV.It has significant effect,worthy of recommendation.

关 键 词：RH 外科手术 恶心呕吐 不良症状 预防效果 

分 类 号：R975.4[医药卫生—药品]