健肝消脂颗粒对非酒精性脂肪肝胰岛素抵抗的影响研究  

The Research of the Effect of the Liver-invigorating and Fat-reducing Particles to the Insulin Resistance of the Nonalcoholic Fatty Liver Disease

作　　者：刘俊[1] 杨龄[2] 刘滢[3] 陈好远[4] 温伟波[5] 

机构地区：[1]云南中医学院第三附属医院,云南昆明650011 [2]云南中医学院中药学院,云南昆明650500 [3]襄阳市中心医院,湖北襄阳441000 [4]湖北中医药大学基础医学院,湖北武汉430061 [5]云南中医学院第一附属医院,云南昆明650021

出　　处：《云南中医学院学报》2014年第1期67-69,共3页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：云南白药;云南中医学院中医药教育创新基金项目(00360504209)

摘　　要：目的主要研究健肝消脂颗粒治疗NAFLD胰岛素抵抗的疗效。方法将患者分为治疗组与对照组,观察分析两者IR,ALT、AST、GGT,TG、TC、LDL-C,WC、BW、BMI的改善情况。结果 1.两组IRI变化程度的差异有显著性意义(P<0.01),治疗组显著优于对照组。2.两组ALT、AST、GGT下降的差异无统计学意义(P>0.05)。3.两组TG、TC下降的差异有显著性意义(P<0.01),LDL-C下降的差异无统计学意义(P>0.05),治疗组显著优于对照组。4.两组WC下降的差异有统计学意义(P<0.05),BW下降的差异无统计学意义(P>0.05),BMI下降的差异有显著性意义(P<0.01),治疗组优于对照组。结论健肝消脂颗粒可以有效治疗NAFLD,可以改善其IR,可以降低ALT、AST、GGT,TG、TC,WC、BMI水平。Objective The main purpose is to research the curative effect of the liver-invigorating and fat-reducing panicles to the insulin resistance of nonalcoholic fatty liver disease. Methods Take patients into two groups, to observe curative effect between two groups, to analyze the reducing of insulin resistance, ALT, AST, GGT, TG, TC, LDL-C, WC, BW, BMI. Results 1. The difference between two groups＇ reducing extent of IRI is significant （P〈0.01）, treatment group is much better than control group. 2. The difference between two groups＇ reducing extent of ALT, AST and GGT （P〉0.05）are not statistically significant. 3. The difference between two groups＇ reducing extent of TG, TC are significant （P〈0.01）, and the difference between two groups＇ reducing extent of LDL-C is not statistically significant（P〉0.05）, treatment group is much better than control group. 4. The difference between two groups＇ reducing extent of WC is statistically significant （P〈0.05）, the difference between two groups＇ reducing extent of BW is not statistically significant （P〉0.05）, the difference between two groups＇ reducing extent of BMI is significant （P〈0.01）, treatment group is better than control group. Conclusion Liver-invigorating and fat-reducing particles can relieve the nonalcoholic fatty liver disease, and relieve the insulin resistant. It can also reduce the level of ALT, AST, GGT, TG, TC, WC, BMI.

关 键 词：健肝消脂颗粒 非酒精性脂肪肝 胰岛素抵抗 

分 类 号：R256.4[医药卫生—中医内科学]