化痰祛瘀通络法对慢性阻塞性肺病急性加重期肺功能及炎性介质的影响  

The Influence of Huatan Quyu Tongluo Method for Acute Exacerbation Period of Chronic Obstructive Pulmonary Disease(AECOPD)of Lung Function and Inflammatory Mediators

作　　者：宋欠红[1] 李云华[1] 邓远芬[2] 吴英[2] 罗庆文[2] 朱虹江[2] 叶勇[2] 

机构地区：[1]云南中医学院,云南昆明650500 [2]云南中医学院第一附属医院,云南昆明650021

出　　处：《云南中医学院学报》2014年第1期73-75,共3页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：云南省教育厅科学研究基金项目(2012C035);云南白药;云南中医学院中医药教育创新基金项目(YB2011J07)

摘　　要：目的观察化痰祛瘀通络法对慢性阻塞性肺病急性加重期肺功能及炎性介质(IL-8、TNF-α)和CRP的影响。方法将80例患者随机分为2组,治疗组给予以化痰祛瘀通络法和西医常规治疗,对照组予以西医常规治疗。比较2种方法疗效,测定血清IL-8、TNF-α、CRP的含量及检测肺功能。结果治疗组与对照组比较,血清IL-8、TNF-α、CRP及肺功能(P<0.05),均有统计学意义。结论化痰祛瘀通络法对慢性阻塞性肺病急性加重期炎性介质(IL-8、TNF-α)有明显的干预作用。能够有效降低IL-8、TNF-α的水平,能够提高FEV1%、FEV1/FVC的水平,有效改善肺功能。Objective To observe the influence of Huatan Quyu Tongluo method for Acute exacerbation period of Chronic obstructive puhnonary disease （AECOPD）of Lung function And inflammatory mediators （IL-8,TNF-α,CRP）. Methods 80 patients were randomly divided into 2 groups, The treatment group to give huatan Huatan Quyu Tongluo method And conventional western medicine therapy. Conventional western medicine treatment control group. Compare two methods of curative effect, The determination of serum IL-8, TNF-α, CRP levels And testing lung function. Results The treatment group compared with control group, Serum IL-8, TNF-α, CRP and lung function（P〈0.05 ）have statistical significance. Conclusion Having obvious intervention effect of Huatan Quyu Tongluo method for Acute exacerbation period of Chronic obstructive pulmonary disease （AECOPD） of Lung function And inflammatory mediators （IL-8 ,TNF-α,CRP）. Can effectively reduce the level of IL-8 ,TNF-α,CRP, To improve the level of FEV1, FEV1/FVC %, Effectively improve lung function.

关 键 词：化痰祛瘀通络法 慢性阻塞性肺病急性加重期 IL-8 TNF-Α CRP 肺功能 

分 类 号：R256.1[医药卫生—中医内科学]