高压氧对左室射血分数保留的心力衰竭患者左室重构的影响  

Hyperbaric oxygen on left ventricular ejection fraction preserved by the influence of left ventricular remodeling in patients with heart failure

作　　者：李继锋[1] 林炳钦 林宝珠[1] 蔡建生[1] 彭志坚[1] 许锦叶 

机构地区：[1]广东省汕头市第二人民医院心内科,515011

出　　处：《实用医学杂志》2014年第5期726-729,共4页The Journal of Practical Medicine

基　　金：汕头市科技计划项目[编号:汕府科(2012)113号]

摘　　要：目的:观察高压氧对左室射血分数保留的心力衰竭(HFpEF)患者左室重构的影响。方法:将110例HFpEF患者随机分为两组,对照组55例应用常规抗心衰药物治疗,治疗组在常规药物治疗基础上加用高压氧治疗,应用彩色多普勒超声检测治疗前及治疗后3个月左心室结构各项指标。结果:两组治疗后,左室结构各项指标(左室舒张末期内径、室间隔舒张末期厚度、左室后壁舒张末期厚度、左室心肌重量指数)均明显下降(P<0.01),治疗组与对照组比较差异有统计学意义(P<0.05)。随访3个月,治疗组发生复合心血管事件较对照组减少且差异有显著性(P<0.05)。结论:高压氧治疗能显著改善HFpEF患者左室舒张和收缩功能,逆转左室重构,并可减少心血管事件的发生。Objective To study hyperbaric oxygen on left ventricular ejection fraction preserved by the influence of left ventricular remodeling in patients with heart failure. Methods A total of 110 patients with heart failure and normal ejection fraction were randomly allocated into the control group （n = 55 ） and the HBO group （n = 55）. The control group were given the routine therapy, the HBO group were treated with hyperbaric oxygen on the basis of conventional drug. The application of color doppler ultrasound before and after treatment for 3 months left ventrieular structure indicators. Results Left ventricular structure indicators were significantly decreased （LVDd, IVSD, LVPWD, LVMI）（P 〈 0.01 ）. Compared with the control group the difference was statistically significant （P 〈 0.05 ）. Follow-up of 3 months, The treatment group composite cardiovascular events was fewer than the control group and had significant difference （P 〈 0.05）. Conclusion Hyperbaric oxygen therapy can significantly improve left ventricular ejection fraction preserved by heart failure of left ventricular diastolic and systolic function and reverse left ventricular remodeling, And can reduce the happening of cardiovascular events.

关 键 词：心力衰竭 高压氧治疗 左室重构 

分 类 号：R541.6[医药卫生—心血管疾病]