金正均Q值法评价维生素C联合维生素E治疗特发性弱精子症的协同作用  

Evaluation of combination therapy with vitamin E and vitamin C for idiopathic asthenospermia by Q value method

作　　者：韩鹏[1] 刘志文[1] 张国钢[1] 肖守允 许宏[1] 王久林[2] 

机构地区：[1]东南大学医学院附属南京同仁医院泌尿外科,南京市211100 [2]江苏省老年医院泌尿外科,南京市210024

出　　处：《实用医学杂志》2014年第5期738-741,共4页The Journal of Practical Medicine

摘　　要：目的:用金正均Q值法评价联合使用维生素C和维生素E治疗特发性弱精子症是否存在协同增效作用。方法:2012年8月至2013年11月男科门诊诊断的76例特发性弱精子症患者,随机分为3组,分别予以维生素E 100 mg每日3次(VitE组)、维生素C 200 mg每日3次(VitC组)以及二药联合口服治疗(合用组)12周,治疗前后采用计算机辅助精液分析系统分析常规参数及动力学参数,并采用硫巴比妥酸法(TBA)检测治疗前后精液中丙二醛(MDA)的浓度,用金正均法计算增效Q值,评价二药合用是否存在协同增效作用。结果:与治疗前相比,治疗后的各组MDA浓度明显降低;3组患者精子活力活率均较治疗前明显改善,但合用组效果更为明显,增效Q值为1.18。结论:联合使用维生素E和维生素C治疗特发性弱精子症具有明显的体内抗氧化协同增效作用。Objective To use Q value method to assess the effect of combination therapy with vitamin E and vitamin C for idiopathic asthenospermia. Methods 76 patients diagnosed as idiopathic asthenospermia by computer-assisted semen analysis according to the WHO criteria were selected at the andrology clinic from August 2012 to November 2013. Malondialdehyde （MDA） concentration was measured by using thiobarbituric acid （TBA） assay. The patients were randomly divided into three groups. Vit C group received vitamin C 200 mg thrice daily, vit E group received vitamin E 100 mg thrice daily, and the combination group received vitamins E and C for 12 weeks. Repeat semen analysis and MDA measurement were conducted after treatment, and the Q value which evaluated whether a synergistic interaction existed was calculated. Results MDA concentration decreased in all the groups, with the lowest concentration in the combination group. While all the groups achieved improvement in term of progressive motility, with the combination group presented far more better than the other two groups, exhibiting a synergistic interaction, with a Q value of 1.18. Conclusion Combination therapy with vitamin E and vitamin C has a marked internal synergistic effect on antioxidation in the treatment of idiopathic asthenospermia

关 键 词：弱精子症 维生素E 维生素C 活性氧 丙二醛 协同增效作用 金正均Q值 

分 类 号：R698.2[医药卫生—泌尿科学]