口服布洛芬治疗早产儿呼吸窘迫综合征并动脉导管未闭的疗效和安全性观察  

The observation on the efficiency and safety of oral ibuprofen in the treatment of premature infant with neonatal respiratory distress syndrome combined with patent ductus arterious

作　　者：杨汉华[1] 黄月君[1] 吴若琪 黄璜[1] 史雪川[1] 

机构地区：[1]汕头大学医学院第二附属医院新生儿科,广东515041

出　　处：《中国临床新医学》2014年第2期118-121,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的观察口服布洛芬治疗早产儿呼吸窘迫综合征(neonatal respriratory distress syndrome,NRDS)并动脉导管未闭(patent ductus arterious,PDA)的疗效和安全性。方法选择呼吸窘迫综合征并动脉导管未闭早产儿38例,出生体重920～2 900 g,胎龄26.57～36.29周。口服布洛芬混悬滴剂10 mg·kg-1·次-1,连用3次。用药期间监测心率、血压、血氧饱和度、血糖、尿量、胆红素、电解质。用药前后检查血常规、肾功能、胆红素、超声心动图。结果经治疗32例(84.21%)PDA关闭。治疗前后血常规、胆红素、尿量、血清肌酐水平均无明显改变。治疗前后血常规、胆红素、尿量、肾功能的变化与胎龄、出生体重、呼吸支持天数、呼吸支持方式、用药日龄与是否应用肺泡表面活性物质(pulmonary surfactant,PS)无关系。结论口服布洛芬治疗早产儿NRDS并PDA安全有效。Objective To investigate the efficiency and safety of oral ibuprofen in the treatment of premature infant with neonatal respiratory distress syndrome （ NRDS） combined with patent ductus arterious （ PDA） .Methods Thirty-eight cases were included .The birth weight was between 920 g and 2 900 g, gestation age was between 26.57 weeks and 63.29 weeks.Ibuprofen suspension was given with dosage 10 mg/kg for 3 times.The heart rate, SaO2,＆amp;nbsp;blood pressure , blood glucose , urine output , bilirubin and electrolyte were monitored during the treatment .The renal function, CBC, bilirubin and echocardiogram were examined before and after the treatment. Re sults PDA was closed in 32 cases（84.21%）.CBC, bilirubin, urine output, and serum creatinine did not show significant changes . The changes of CBC, bilirubin, urine output, renal function was not related with neither birth age , birth weight, days of breath support , method of breath support , day of drug given nor whether the application of pulmonary surfactant . Conclusion Oral ibuprofen is effective and safety in closing PDA in premature infant with NRDS .

关 键 词：早产儿 新生儿呼吸窘迫综合征 动脉导管未闭 布洛芬 

分 类 号：R722[医药卫生—儿科]