正常未成年人脑内灰质核团相位值的测量  

Measurement of phase value of the deep gray nuclei in underage brain

作　　者：张雷[1] 陈涛[2] 宁宁[3] 任转琴 罗俊[3] 党少农[4] 杨健[3] 

机构地区：[1]宝鸡市中心医院磁共振室,721008 [2] 宝鸡市中心医院磁共振室 [3]西安交通大学医学院第一附属医院影像科,710061 [4] 西安交通大学医学院公共卫生系

出　　处：《中华放射学杂志》2014年第2期146-150,共5页Chinese Journal of Radiology

基　　金：国家自然科学基金资助项目（81171317）;教育部新世纪优秀人才计划（DWYXSJ11000007）;陕西省社会发展攻关计划（2010K15-064）4）

摘　　要：目的 应用磁敏感加权成像（SWI）技术测量正常未成年人脑内深部灰质核团的相位值,观察其随年龄变化的规律.方法 选取105名相对健康未成年人（0～18岁）,按照发育周期分成5组,即婴儿期（60名）、幼儿期（10名）、学龄前期（10名）、学龄期（10名）、青春期（15名）,均进行MRI常规序列和SWI扫描,分别测量双侧尾状核、壳核、苍白球、丘脑、红核及黑质的相位值,运用Spearman秩相关分析观察感兴趣区内相位值随年龄的变化规律.结果 婴幼儿期的尾状核相位值在同年龄组内所测核团中最低（婴儿期：左侧-0.0433±0.0291、右侧-0.0369±0.0215,幼儿期：左侧-0.0369±0.0215、右侧-0.0384±0.0259）,而红核相位值在同年龄组内最高（婴儿期：左侧0.0286±0.0380、右侧0.0254±0.0361,幼儿期：左侧0.0325±0.0237、右侧0.0395±0.0270）；幼儿期以后,苍白球相位值在同年龄组内最低（学龄前期：左侧-0.0967±0.0656、右侧-0.0953±0.0617;学龄期：左侧-0.1870±0.0531、右侧-0.1724±0.0547；青春期：左侧-0.2037±0.0492、右侧-0.1849±0.0324）,除学龄前期左侧丘脑外,其他丘脑相位值在同年龄组内最高（学龄前期：右侧-0.0007±0.0167；学龄期：左侧-0.0067±0.0104、右侧-0.0064±0.0118；青春期：左侧-0.0204±0.0181、右侧-0.0172±0.0133）,且均为负值.未成年人脑内深部灰质核团相位值随年龄增长而降低,左右侧尾状核、苍白球、红核及黑质的相位值与年龄呈中度负相关（rs分别为-0.483、-0.497,-0.67、-0.621,-0.489、-0.43,-0.552、-0.58）,左右侧壳核及丘脑的相位值与年龄呈低度负相关（rs分别为-0.272、-0.213,-0.382、-0.366）,均具有统计学意义（P值均＜0.01）.结论 未成年人脑内深部灰质核团相位值与年龄呈负相关,相位值可为与铁质沉积相关疾病的诊断提供参考.Objective To measure the phase values of the deep gray nuclei by using susceptibility weighted imaging（SWI） in underage brains,and to investigate the correlation between the phase value and age.Methods A total of 105 healthy juveniles were examined in this study by using MRI conventional sequence and SWI.Their ages ranged from 0 to 18 years（0-〈 1 year,60 cases; 1-〈3 years,10 cases; 3-7 years,10 cases; 7-12 years,10 cases; 12-18 years,15 cases）.Phase values of deep gray nuclei were measured.The correlation between phase value and age was analyzed by Spearman correlation method.Results During 0-3 years,the phase value of caudate nucleus was the lowest within the same age group （0-〈 1 year：left-0.0433 ± 0.0291,right-0.0369± 0.0215 ; 1-〈 3 years：left-0.0369 ±0.0215,right-0.0384 ± 0.0259）,whereas the phase value of red nucleus was the highest （0-〈 1 year：left 0.0286-0.0380,right 0.0254 ＆#177;0.0361 ; 1-〈3 years：left 0.0325±0.0237,right 0.0395±0.0270）.After 3 years old,the phase value of globus pallidus was the lowest within the same age group （3-〈7 years：left-0.0967±0.0656,right-0.0953 ± 0.0617; 7-〈 12 years：left-0.1870± 0.0531,right-0.1724 ±0.0547; 12-〈 18 years：left-0.2037 ±0.0492,right-0.1849±0.0324）,whereas the phase value of thalamus was the highest （3-〈 7 years：left-0.0019 ± 0.0225,right -0.0007 ± 0.0167 ; 7-〈 12 years：left-0.0067 ± 0.0104,right-0.0064± 0.0118 ; 12-〈 18 years：left-0.0204±0.0181,right-0.0172 ± 0.0133）.During 0-18 years,a moderate negative correlation between phase values of bilateral caudate nucleus,globus pallidus,red nucleus,substantia nigra and age were observed （rs =-0.483,-0.497,-0.67,-0.621,-0.489,-0.43,-0.552,-0.58 respectively） A low negative correlation between phase values of bilateral putamen,thalamus and age were observed （rs =-0.272,-0.213,-0.382,-0.366 respectively）.Conclusions There is a negative correlation between phase value and age in the deep gray nuclei of underage brains.And the p

关 键 词：磁共振成像 脑 年龄因素 

分 类 号：R816.92[医药卫生—放射医学]