Hedgehog信号通路与骨质疏松症  

Hedgehog signaling pathway and osteoporosis

作　　者：罗明[1] 黄宏兴[1] 黄红[1] 李泽钿[1] 赖圆圆 

机构地区：[1]广州中医药大学附属骨伤科医院骨科,广东广州510240

出　　处：《中国骨伤》2014年第2期169-172,共4页China Journal of Orthopaedics and Traumatology

基　　金：国家自然科学基金(编号:81373653;81302991)~~

摘　　要：Hedgehog信号通路是一条保守而重要的信号通路,涉及到多种细胞的增殖和分化活动。近年研究发现,Hedgehog信号通路可以通过上调Runx2和Osx等主要转录因子的表达促进间充质干细胞(mesenchymal stem cells,MSCs)向成骨细胞分化,并且抑制MSCs向脂肪细胞分化。Hedgehog信号通路还可以通过调节细胞周期蛋白促进成骨细胞增殖。本文综述总结了Hedgehog信号通路调节成骨细胞增殖分化的作用机制,认为Hedgehog信号通路通过促进成骨细胞增殖分化参与调节骨代谢,为骨质疏松症的治疗提供一种新思路。Hedgehog signaling pathway is a conserved and important signaling pathway involved in proliferation and dif- ferentiation of many types of ceils. Latest studies have found that Hedgehog signaling pathway may induce MSCs osteoblast dif- ferentiation by increasing the expression of the Runx2 and Osx and inhibit MSCs differentiate to adipocyte. Hedgehog signaling pathway may also promote osteoblast proliferation by regulating cyclin. This review summarizes the mechanism that Hedgehog signaling pathway regulates osteoblast differentiation and proliferation,and concludes that Hedgehog signaling pathway can regulate bone metabolism. It might provide new ideas for the treatment of osteoporosis.

关 键 词：HEDGEHOG信号通路 成骨分化 骨质疏松症 

分 类 号：R542.2[医药卫生—心血管疾病]