款冬花多糖对荷瘤小鼠的抑瘤率及对白血病小鼠生存期的影响  

Effect of Tussilago farfara L. polysaccharide on tumor-inhibition rate and survival-extending rate in tumor or leukemia bearing mice

作　　者：余涛[1] 宋逍[1] 赵鹏[1] 刘思[1] 段玺[2] 

机构地区：[1]陕西中医学院药学院,陕西咸阳712046 [2]陕西中医学院附属医院,陕西咸阳712046

出　　处：《中南药学》2014年第2期125-128,共4页Central South Pharmacy

基　　金：陕西省自然科学基金(No.2011JQ2005);陕西省教育厅科研专项(No.2013JK0764);陕西省中药制药重点学科专项基金资助

摘　　要：目的研究款冬花多糖对荷瘤小鼠的抑瘤率和对白血病小鼠生存期的影响,并探讨其抗肿瘤机制。方法以小鼠肉瘤(S180)、小鼠肝癌(H22)瘤株及小鼠网状细胞白血病(L615)瘤株造模,设正常对照组、阳性药物组、款冬花高剂量组和款冬花低剂量组4组,考察款冬花多糖对各组小鼠抑瘤率和对白血病生存期的影响。结果款冬花多糖对S180、H22小鼠的抑瘤率分别为55.76%、45.61%;对L615白血病小鼠生命延长率>55.76%。结论款冬花多糖是抗肿瘤、抗白血病的有效药物,可干扰肿瘤细胞的有丝分裂过程和提高机体免疫力。Objective To investigate the effect of Tussilago farfara L. polysaccharide on the tumor-inhibition rate and the survival-extending rate of S180 and H22 mice and to analyze its antitumor mechanism. Methods Cell strain S180, H22 and L615 were inoculated in the experimental mice, which were divided into 4 groups later（a blank group, a normal group, a high dose group and a low dose group）. After 7 days of ig administration, the mice were executed and tumor tissue was extracted, then the tumor-inhibition rate and the survival-extending rate were calculated. Results The average tumor-inhibition rates on S180 and H22 were above 55.76% and 45.61%, respectively. The survival-extending rate on L615 mice was above 55.76%. Conclusion Tussilago farfara L. polysaccharide not only can suppress the growth of S180 and H22, but also extend the survival of L615 leukemia mice. The anticancer mechanism may facilitate the microtubule aggregating in the middle of intermitotic cells, disturbing the kargomitosis course of cancer cells and enhancing the immunity of body.

关 键 词：款冬花 多糖 肿瘤 白血病 

分 类 号：R965[医药卫生—药理学]