白念珠菌、烟曲霉及新生隐球菌感染的宿主特异性免疫应答研究进展  

Specific immune responses to Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans infection in host

作　　者：张金侠[1] 刘维达[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042

出　　处：《国际皮肤性病学杂志》2014年第2期129-132,共4页International Journal of Dermatology and Venereology

基　　金：国家重点基础研究发展计划（973计划）（2013CB531605）

摘　　要：白念珠菌、烟曲霉及新生隐球菌是3种机会致病真菌。这些真菌一旦感染人体，即与机体免疫系统相互作用，激活机体的天然免疫，继而产生特异性细胞免疫及体液免疫应答，其中特异性细胞和体液免疫应答对宿主抵御感染和防止菌体免疫逃逸发挥重要作用。概述近几年有关白念珠菌、烟曲霉及新生隐球菌感染的特异性免疫应答的研究现状，并分析3种真菌免疫的异同点，以期为开展此类研究提供有益借鉴。Candida albicans, Aspergillus fumigates and Cryptococcus neoformans are three important human opportunistic pathogens. Once these fungi enter the human body, they interact with immune system of the host, and cause innate immune responses followed by specific cellular and humoral immune responses, which are of great importance for the host defense against funga] infection and prevention of fungal escape from the host immune system. The authors highlight the current status of research in specific immune responses to C. albicans, A. fumigatus and C. neoformans infection, and analyze similarities and differences between the three fungi, in hope to provide clues for further esearch in this field.

关 键 词：念珠菌  白色 曲霉菌  烟 隐球菌  新型 免疫 

分 类 号：R756[医药卫生—皮肤病学与性病学]