抗SSA、抗SSB、抗α-胞衬蛋白抗体及类风湿因子联合检测在原发性干燥综合征的诊断价值  

Diagnostic value of anti-SSA,anti-SSB,anti-α-fodrin antibody and RF in the diagnosis of Sj（o）gren′s Syndrome

作　　者：殷寒秋[1] 马华[1] 刘春梅[1] 李朝虹[1] 张婷[1] 蒋培培[1] 

机构地区：[1]徐州医学院附属医院风湿免疫科,江苏徐州221002

出　　处：《徐州医学院学报》2014年第1期41-43,共3页Acta Academiae Medicinae Xuzhou

摘　　要：目的 研究抗干燥综合征A抗体（抗SSA）、抗干燥综合征B抗体（抗SSB）、抗α-胞衬蛋白抗体（抗α-fodrin）及类风湿因子（RF）联合检测对原发性干燥综合征的诊断价值.方法 检测75例干燥综合征（SS）[原发性SS 35例（pSS组）、继发性SS 40例（sSS组）]、80例其他结缔组织病（非SS的CTD组）及80例健康对照者（健康对照组）血清中抗核抗体（ANA）、RF、抗SSA、抗SSB、抗α- fodrin,比较各抗体诊断的敏感性和特异性.结果 抗SSA、抗SSB、抗α-fodrin、ANA、RF在pSS组敏感性分别为77.1%、62.9%、25.7%、80%、51.4%;3种特异性抗体联合RF检测的敏感性高于单一抗体,而四者联合检测时敏感性达91.4%;在抗SSA或抗SSB均阴性时,抗α-fodrin联合RF的敏感性为75%.结论 抗α-fodrin与抗SSA、抗SSB、RF的联合检测可提高pSS的诊断率;抗SSA、抗SSB阴性时联合检测抗α-fodrin和RF可避免漏诊.Objective To explore the diagnostic value of anti - SSA, anti - SSB, anti - α - fodrin antibody and rheumatoid factor （RF） in the diagnosis of Sj0gren＇s Syndrome （SS）. Methods Serum antinuclear antibody （ANA）, anti - SSA, anti - SSB, anti - α - fodrin antibody, and RF of patients with primary SS （ pSS group, n = 35 ） , secondary SS （sSS group, n =40）, other non- SS connective tissue diseases （non- SS CTD group, n = 80）, and healthy subject （ normal control group, n = 80） were detected, and their sensitivities and specificities were compared. Results In pSS group, the specificities of anti - SSA, anti - SSB, anti - α - fodrin antibody, ANA, and RF for pSS were 77. 1% , 62.9% , 25.7% , 80%, and 51.4% respectively. The specificity of the three species antibody with RF by joint detection was significantly higher than single antibody, the specificity was 91.4%. When anti - SSA and anti - SSB antibodies were all negative, the specificity of anti -α - fodrin and RF was 75 %. Conclusions The joint detection of anti - SSA, anti - SSB, anti -α - fodrin antibody and RF can elevate the rate of diagnosis for SS. When anti - SSA and anti - SSB antibody are all negative, the joint detection of anti - α - fodrin antibody and RF can avoid misdiagnosis.

关 键 词：干燥综合征 抗Α-胞衬蛋白抗体 抗干燥综合征A抗体 抗干燥综合征B抗体 类风湿因子 

分 类 号：R593[医药卫生—内科学]