过敏性紫癜患儿早期肾损害保护作用探讨  

Study on the protective effect of children with early renal damage caused by Henoch-Sch（o）nlein purpura

作　　者：丁娴[1] 冯仕品 郑东辉[3] 吴宏图[1] 汪海敏[1] 单春明[1] 

机构地区：[1]淮安市第二人民医院儿科,江苏淮安223002 [2]成都市妇女儿童医院肾内科,四川成都610017 [3]淮安市第二人民医院肾内科,江苏淮安223002

出　　处：《徐州医学院学报》2014年第1期44-47,共4页Acta Academiae Medicinae Xuzhou

摘　　要：目的 探讨孟鲁司特钠对过敏性紫癜（Henoch-Sch（o）nlein purpura,HSP）患儿早期肾损害的保护作用.方法 将103例尿常规检查正常的HSP患儿随机分成2组,对照组给予常规治疗,干预组在常规治疗的基础上加用孟鲁司特钠治疗.2组分别于入院时,治疗后1个月、3个月进一步检测尿微量蛋白[免疫球蛋白G（IgG）、微量白蛋白（ALB）、转铁蛋白（TRF）、α1-微球蛋白（α1-MG）、β2-微球蛋白（β2-MG）]和尿酶[N-乙酰-β-D氨基葡萄糖苷酶（NAG）]的含量.治疗第1个月每周检测1次尿常规,以后每半个月1次,3个月后每月1次,随访半年;比较临床肾损害的发病率及临床分型.结果 103例尿常规检查正常的HSP患儿中尿微量蛋白和尿酶异常87例（84.46%）.干预组治疗后1个月、3个月尿微量蛋白、尿酶各项指标均较治疗前降低,差异有统计学意义（P〈0.05或P〈0.01）;干预组临床肾损害发病率及临床分型较对照组明显降低（P〈0.05）.结论 孟鲁司特钠对过敏性紫癜患儿早期肾损害具有保护作用,可能对过敏性紫癜肾损害有预防作用.Objective To investigate the protective effect of montelukast sodium on early renal damage in children with Henoch -Scht^nlein purpura （HSP）. Methods 103 cases of HSP children with normal routine urine examination results were divided into two groups at random. The control group was given conventional therapy. The intervention group was treated with montelukast sodium together with conventional therapy. Both groups received test of urinary protein fami- ly - - immunoglobulin G （ IgG）, transferrin （ TRF）, microalbumin （ ALB）, otl- microglobulin （ ctl - MG）, and[32 - microglobulin （ 132 - MG）, and urinary enzymes （ NAG ） on admission, 1 month and 3 months after treatment. In the first month, urine routine was tested once a week, then once half a month for another 2 months, and once a month till half a year, after treatment to compare the incidence and clinical classification of clinical renal damage. Results Among the 103 patients with normal urine routine test findings, there were 87 cases （84.46%） having abnormal findings of renal function hiomarkers. Trace protein urine, urinary enzyme indicators of intervention group was significantly reduced （P 〈 0.05 or P 〈 0.01 ） compared with the control group. The incidence of clinical renal damage and clinical classification of intervention group also had differences compared with control group （P 〈 0.05 ）. Conclusion Montelukast sodium plays a protective role for children with early renal damage caused by I-ISP and may prevent the renal damage in HSP.

关 键 词：孟鲁司特钠 过敏性紫癜 肾损害 早期干预 儿童 

分 类 号：R725.9[医药卫生—儿科]