IL13基因rs1295686多态性与北方汉族儿童哮喘易感性的关联分析  

Association study of rs1295686 polymorphisms in IL13 gene with pediatric asthma in a northeastern Han Chinese population

作　　者：王懿[1] 李天晓[1] 邓颖[2] 宋娟娟[2] 张海英[2] 周宏博[1] 

机构地区：[1]哈尔滨医科大学生物化学与分子生物学教研室 [2]哈尔滨医科大学附属第二医院急诊科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2014年第1期1-4,共4页Journal of Harbin Medical University

基　　金：黑龙江省自然科学基金资助项目(D201204)

摘　　要：目的研究白细胞介素13（IL13）基因SNP位点rs1295686多态性与北方汉族儿童哮喘易感性的关系。方法采用SNaPshot方法对435例哮喘儿童和601例对照儿童的IL13基因位点rs1295686和对照位点rs9312717进行分型检测，并进行统计学分析。结果IL13基因rs1295686位点的T风险等位基因频率分布在病例一对照组中差异显著（P=0．012，OR：1．265，95％CI1．052～1．520）。对照位点rs9312717在两组中差异无显著性（P=0．359）。通过logistic回归分析rs1295686位点的基因型在病例一对照组中的分布，发现T基因型纯合子携带者发生哮喘的相对危险度较携带纯合CC基因型、杂合CT基因型者显著增高（P=0．026，OR=1．568，95％CI1．055～2．330）。结论IL13基因SNP位点rs1295686多态性与北方汉族儿童哮喘易感性具有显著相关性。Objective To investigate the association between the rs1295686 polymorphism of ILl3 gene and asthma in northeastern Han Chinese children. Methods SNP rs1295686 of ILl3 gene and control SNP rs9312717 in 435 pediatric asthma patients and 601 healthy controls were genotyped by using SNaPshot method. Statistical analysis were performed by using SPSS 19.0 software. Results A significant difference was found in rs1295686 allele frequency be- tween case group and control group （P = 0. 012, OR = 1. 265, 95% CI 1. 052 - 1. 520）. However, but there was no difference for control SNP rs9312717 between two groups （P 〉 0. 05）. In addition, genotype analysis of rs1295686 used logistic regression showed that the homozygous carriers of the at-risk allele TF had a significant increased asthma risk comparedwith the other allele carriers, such as CT and CC （P =0. 026, OR = 1. 568, 95% CI 1. 055 2. 330）. Conclusion Polymorphisms of ILl3 gene rs1295686 is associated with childhood asthma in Han population of northeastern China.

关 键 词：哮喘 北方汉族儿童 IL13基因 单核苷酸多态性 rs1295686 

分 类 号：R725.6[医药卫生—儿科] R34[医药卫生—临床医学]