中药内服治疗新鲜骨折的Meta分析  

Effectiveness and Safety of Traditional Chinese Medicine for Fresh Fractures Patients: A Meta-analysis

作　　者：张春玲[1] 阮震寰 张乐[1] 郭增军[1] 

机构地区：[1]西安交通大学医学院附属红会医院药学部,西安710054

出　　处：《中国实验方剂学杂志》2014年第6期204-211,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(8117295)

摘　　要：目的:系统评价中药治疗新鲜骨折的有效性和安全性。方法:电子检索中文科技期刊全文数据库(VIP)、中国期刊全文数据库(CNKI)、万方数据库、中国生物医学数据库(CBM)、PuBMED、Cochrane图书馆,手工检索相关期刊,收集中药内服治疗新鲜骨折的RCT。检索时限均从建库至2012年12月31日。由2名研究人员依据纳入与排除标准选择试验、提取资料和评价质量后,采用RevMan 5.1.4软件进行Meta分析。结果:纳入30个RCT,共3 451例患者,Meta分析结果显示:与对照组比较,中药内服更能提高骨折愈合的有效率[OR=3.02,95%CI(1.59,5.74),P=0.000 8;OR=3.30,95%CI(1.86,5.87),P<0.000 1];缩短骨折临床愈合时间[MD=-15.15,95%CI(-23.90,-6.41),P=0.000 7;MD=-14.33,95%CI(-16.41,-12.25),P<0.000 01];改善临床症状[MD=-0.80,95%CI(-1.12,-0.48),P<0.000 01]。结论:中药内服治疗新鲜骨折可以提高临床治疗效果,促进骨折愈合。由于纳入研究为低质量,降低了本系统评价的证据强度,故系统评价的结论仅供临床实践与研究参考。Objective：To evaluate the effectiveness and safety of traditional Chinese for fresh fractures patients.Method：Such databases as VIP,CNKI,CBM,Wanfang Data,PuBMED and the Cochrane library were searched electronically from the date of thief establishment to December 31 2012,and other relevant journals were also searched manually.Two reviewers independently screened the studies in accordance with the inclusion and exclusion criteria,extracted data and assessed methodology quality.Then the meta-analysis was performed using RevMan 5.1.4 software.Result：A total 30 RCT involving 3 451 patients were included,the results of meta-analysis showed that compared with control group,Chinese medicine internal and more can improve the efficient of fracture healing [OR=3.02,95％CI （1.59,5.74）,P=0.000 8; OR=3.30,95％CI （1.86,5.87）,P＜0.000 1]; Shorten the clinical healing time [MD=-15.15,95％CI （-23.90,-6.41）,P=0.0007; MD=-14.33,95％CI （-16.41,-12.25）,P＜0.00001]; Improved clinical symptoms [MD=-0.80,95％ CI （-1.12,-0.48）,P ＜ 0.000 01].Conclusion：Traditional Chinese medicine internal can improve the clinical therapeutic effect,promote fracture healing.For quality of the included studies which decreases the level of evidence,so the conclusion of this Systematic review only provides some reference for clinical practice and research.

关 键 词：中药内服 骨折 安全性 随机对照试验 META分析 系统评价 

分 类 号：R287[医药卫生—中药学]