奥扎格雷钠联合舒血宁注射液治疗急性脑梗死的系统评价  

Systematic Review of Ozagrel Sodium Combined with Shuxuening Injection in Treatment of Acute Cerebral in Farction

作　　者：柴劲[1] 王莉梅[2] 李金东[3] 朱大胜[1] 刘行梅[1] 金向群[4] 姚铭[2] 史春山 付秀娟[1] 

机构地区：[1]吉林大学第二医院药品管理部,长春130011 [2]吉林大学第四医院药学部,长春130011 [3]吉林大学第二医院胸外科,长春130011 [4]吉林大学药学院,长春130011 [5]解放军二零八医院四六一临床部药剂科,长春130011

出　　处：《中国实验方剂学杂志》2014年第6期211-216,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：吉林省科技成果项目(2013042)

摘　　要：目的：系统评价奥扎格雷钠联合舒血宁注射液治疗急性脑梗死的疗效和安全性.方法：通过计算机在万方医学数据库、中国知网、维普数据库及Cochrane图书馆、Medline/PubMed医学数据库检索2000-2013年国内外已经公开发表的关于奥扎格雷钠联合舒血宁注射液治疗急性脑梗死的临床随机对照试验的相关文献,筛选文献并应用Review Manager 5.1.7做M eta分析.结果：共纳入19个随机对照试验.分析显示,奥扎格雷钠联合舒血宁注射液治疗急性脑梗死的神经功能缺损临床疗效比值比（0R）合并值为3.92（95％可信区间为2.99 ～ 5.14）.神经功能缺损评分疗效加权均数差（WMD）合并值为1.06（95％可信区间为-2.92 ～5.05）.结论：奥扎格雷钠联合舒血宁注射液治疗急性脑梗死临床疗效确切,未见明显不良反应,但仍需要更多严格、多中心的随机双盲对照试验提供有力证据.Objective：To assess the curative effect and safety of Shuxuening injection combined with Ozagrel Sodium Injection in the treatment of acute cerebral infarction （ACI） with Meta analysis method.Method：The randomized controlled clinical trials of Shuxuening injection combined with Ozagrel Sodium Injection for the treatment of ACI from 1989-2012 were searched by computer-based on line search,and the data was statistically analyzed by Review Manager 5.1.7.Result：The results showed that there were 19 literatures which incorporated by Meta-analysis and the criterion were homogenous,Fixed effect model statistics and analysis showed that the OR （95％CI） was 3.92 （2.99-5.14）.WMD （95％ CI） was 1.06 （-2.92-5.05）.Conclusion：Meta analysis shows that Shuxuening injection combined with Ozagrel Sodium Injection is effective for ACI and it can improve the clinlcal symptom and neurologic impairment in the treatment of ACI without obvious ADR.However,more strict and multi-center randomized double-blinded clinical trailss are needed in order to provide more convinced evidence.

关 键 词：奥扎格雷钠 舒血宁注射液 急性脑梗死 META分析 

分 类 号：R287[医药卫生—中药学]