心肌早期预适应与晚期预适应的协同作用  

Early Proconditioning and Late Proconditioning Can Yield Additive Cardiac Protection

作　　者：郑斌[1] 郑海亮 党瑜华 

机构地区：[1]中国人民解放军289医院,山西侯马043000 [2]侯马市文体委,山西侯马043000

出　　处：《山西师范大学学报（自然科学版）》2000年第4期77-79,共3页Journal of Shanxi Normal University(Natural Science Edition)

摘　　要：探讨心肌早期预适应与晚期预适应之间是否存在协同作用 .方法 :采用热处理方法诱导晚期预适应 ,吗啡静脉注射诱导早期预适应 ,腹腔注射异丙基肾上腺素复制在体心肌梗死模型 .结果 :热处理和吗啡分别可诱导晚期与早期预适应 ,改善心肌梗死后的心功能 .热处理后再予吗啡预适应可进一步改善心肌梗死后的心功能 .结论 :心肌早期预适应与晚期预适应可产生协同作用 。To test the hypothesis that early preconditioning and late preconditioning can yield additive cardiac protection. Method: All rats were divided into four groups. Myocardial infarction was achieved by isoprenaline(ip). EP or DP was achieved by morphine injection or heat stress. Results: EP and DP group′s heart function were better than controls. EP+DP group′s heart funtion was better than control, EP or DP groups. Conclusion: We draw the conclusion that EP and DP can yield additive cardiac protection since they have differential mechanisms.

关 键 词：心肌梗死 吗啡 热休克 早期预适应 晚期预适应 协同作用 热处理方法 心肌保护 

分 类 号：R331.31[医药卫生—人体生理学]