糖尿病患者红细胞镁和蛋白酪氨酸磷酸酶的关系  

Relationship between Erythrocyte Magnesium and Protein Tyrosine Phosphatase in Diabetes Mellitus

作　　者：刘洪斌[1] 郑彤 杨志芬 王克勤 

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]宁波市李惠利医院,浙江宁波315040

出　　处：《宁波大学学报（理工版）》2000年第1期108-110,共3页Journal of Ningbo University：Natural Science and Engineering Edition

基　　金：宁波大学基金!(986701)

摘　　要：目的：探讨了糖尿病患者红细胞镁、蛋白酪氨酸磷酸酶（ＰＴＰ）和血糖的关系．方法： 用葡萄糖氧化酶法和放免法分别测定３０例糖尿病患者（ＤＭ）和２０例正常对照组（ＮＴ）空 腹血糖（ＦＧＰ）胰岛素浓度（ＦＩＮＳ），等离子体原子发射光谱法测定红细胞镁，酶联免疫法测 定红细胞胞浆ＰＴＰ活性、结果：ＤＭ组年龄，体重和体重指数（ＢＭＩ）与ＮＴ组相比无显著性； 年龄（岁）：（５７．３３ ± ７．２１ｖｓ（５８，３５±７，７１）；体重（ｋｇ）；（６１．００±８．２９）ｖｓ（６１．９５±６．９６）； ＢＭＩ（ｋｇ· ｍ^（－２））：（２３．５０± ２．５０）ｖｓ（ ２３４０± ２．７０）；收缩压（ｋＰａ）：（１６，４１± ０．９５ｖｓ （６．７６ ± ０．９８）；舒张压（ｋＰａ）：（９．９６ ± ０．６６）ＶＳ（１０．２８ ± ０．７３），ＤＭ组ＦＧＰ和ＰＴＰ活性显 著高于ＮＴ组（ＦＧ（ｍｍｏｌ·Ｌ^（－１））：（１０．０３±２．０１）ｖｓ（５．１６±０．７０），Ｐ＜０．００１；ＰＴＰ活性 （Ｕ）：（８．４０±１．９９） ｖｓ（６．１７± ２．８４）， Ｐ〈 ００５）； ＤＭ组红细胞镁显著低于 ＮＴ组（Ｍｇ （ｕｍｏｌ·ｇ^（－１））（５．４８± ０．６６）Objective: The relationship among erythrocyte magnesium, fasting plasma glucose and PTP in diabetes mellitus is analyzed. Methods: Thirty patients with diabetes and tweenty health subjects are studied. The erythrocyte magnesium concentrations. fasting plasma glucose(FPG), fasting plasma insulin(FINS) and activity of erythrocyte PTP are measured. Results: show that erythrocyte magnesium is lower in diabetic subjects than controls(p<0.001), FGP and PTP activity are higher in diabetic subjects than controls(p<0.001, p<0.05,respectively) .Interestingly, there is significantly negative correlation between erythrocyte magnesium and PTP activity(r = -0.58,P, 0.01) .In addition, there is a significantly positive relationship between FPG and mp activity(r=0.81, p<0.01). Conclusion: Reduced erythrocyte magnesium and increased PTP activity contribute to high glucose in diabetic subjects.

关 键 词：糖尿病 红细胞 镁 蛋白酷氨酸磷酸酶 血糖 葡萄糖氧化法 放免法 胰岛素度 PTP活性 

分 类 号：R587.102[医药卫生—内分泌]