参倍固肠胶囊治疗脾肾阳虚型肠易激综合征临床观察  

Study on Efficacy of Shen-Bei-Gu-Chang Capsule in Treatment of Irritable Bowel Syndrome Diarrhea

作　　者：廖静[1] 熊炬[1] 

机构地区：[1]内江市中医医院内四科,四川内江641000

出　　处：《成都中医药大学学报》2014年第1期75-77,共3页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：华西药物研究所课题(编号:XAN2011-01-01)

摘　　要：目的:参与完成参倍固肠胶囊治疗脾肾阳虚型IBS的III期临床试验,并观察其临床疗效。方法:将92例脾肾阳虚型IBS-D患者实验组46例和对照组46例,实验组服用参倍固肠胶囊,对照组口服固本益肠片模拟剂,4 w作为观察周期。结果:实验组总有效率为86.7%,对照组为64.4%。2组总有效率比较有统计学意义(P<0.05),实验组在大便性状、大便次数、倦息乏力、腰膝酸痛4项症状改善上优于对照组(P<0.05),但在腹胀腹痛症状改善上两组无显著性差异(P>0.05)。结论:参倍固肠胶囊对脾肾阳虚型IBS-D有效。Objective： To finish part of clinical trials on Shen-bei-gu-chang Capsules, and explore the efficacy of it in treatment of irritable bowel syndrome-diarrhea （IBS-D）. Methods： The selected ninety-two patients with IBS-D were randomly divided into experinren- tal group （ n =46 eases） and control group （ n = 45cases） . Patients in experimental group were administered with Shen-bei-gu-chang cap- sules for two weeks. Patients in control group were administered with simulation agent of Gu-ben-yi-chang Tablets for two weeks, and then followed up for two more weeks. Results： The total effective rate of the expe,~mental group and the control group was 86. 7% and 64. 4% re- spectively, and there was a significant difference between groups （P 〈0. 05） . Conclusion： Shen-bei-gu-chang Capsules and Gu-ben-yi- chang Tablets can alleviate symptoms on patients with IBS-D, Shen-bei-gu-chang Capsules has more obvious effect.

关 键 词：参倍固肠胶囊 肠易激综合征 腹泻型 脾肾阳虚 

分 类 号：R289.5[医药卫生—方剂学] R249.8[医药卫生—中药学]