特发血小板减少性紫癜患者血小板平均容积检测的临床价值  

The detection of MPV in patients with idiopathic thrombocytopenic purpura

作　　者：李江[1] 张然蓉[1] 李钢[1] 罗历[1] 郝建华[1] 

机构地区：[1]深圳市南山区人民医院检验科,广东深圳518052

出　　处：《中国现代医生》2014年第9期71-73,共3页China Modern Doctor

摘　　要：目的 观察特发血小板减少性紫癜（ITP）患者血小板平均体积（MPV）、血小板平均分布宽度（PDW）、大血小板比率（P-LCR）及血小板计数（Plt）的动态变化,并探讨其相关的临床意义.方法 收集我院2011年6月～2013年1月诊治的特发性血小板减少性紫癜患儿88例,另取我院保健门诊体检的健康儿童40例作为对照,全自动血细胞分析仪检测各样本Plt、MPV、PDW及P-LCR血小板参数的变化.结果 对照组Plt显著高于ITP组（P＜0.01）,而对照组MPV、PDW及P-LCR显著低于ITP组（P＜0.01）.Plt、MPV、PDW及P-LCR血小板参数在轻度组、中度组、重度组之间存在显著性差异（P＜0.05）,Ph会随着病情的加重逐渐减低（P＜0.05）,然而MPV、PDW及p-LCR则随着病情的加重逐渐升高（P＜0.05）.ITP患者治疗后Plt较治疗前显著升高（P＜0.01）,而MPV、PDW及p-LCR则显著减低（P＜0.01）.结论 Plt、MPV、PDW及P-LCR血小板参数的检测有助于ITP的鉴别诊断、病情判断及疗效观察.Objective To investigate the clinical efficacy of MPV, PDW, P-LCR, and Pit in patients with idiopathic thrombocytopenic purpura （ITP）. Methods A total of 88 children with ITP were enrolled in this study. Another 40 healthy children were used as control. the MPV, PDW, P-LCRD, and Pit were detected by Sysmex XE-2100. Re- suits The Plt was higher in control group than that in ITP group （P〈0.01）. However, the MPV, PDW, and P-LCRD was lower in control group than that in ITP group （P〈0.01）. There was significant difference of Plt, MPV, PDW and P-LCR among mild, middle, and severe group（P〈0.05）. Compared before treatment, Ph was increased after treatment （P〈0.01）, and MPV, PDW, and P-LCRD was decreased（P〈0.01 ）. Conclusion Ph, MPV, PDW, and P-LCR play a key role in diagnosis and prognosis of ITP, or observing the effectiveness of therapy of ITP.

关 键 词：特发血小板减少性紫癜 血小板平均体积 血小板平均分布宽度 大血小板比率 

分 类 号：R554.6[医药卫生—血液循环系统疾病]