Obestatin与冠状动脉粥样硬化心脏病的相关性分析  

Analysis of correlation between obestatin and coronary atherosclerotic heart disease

作　　者：严爱芬[1] 陈捷[1] 

机构地区：[1]浙江省余姚市人民医院检验科,浙江余姚315400

出　　处：《中国现代医生》2014年第9期138-140,143,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2011KYA147)

摘　　要：目的探讨Obestatin水平与冠状动脉粥样硬化心脏病(CHD)的相关性。方法选取行冠状动脉造影确诊CHD患者90例(观察组),选取同期在体检中心检查的健康人60例(对照组)。检测血清Obestatin、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、纤维蛋白原(Fg)等指标的浓度,探究Obestatin水平与CHD的关系。结果观察组患者Obestatin水平较对照组显著升高(P<0.01)。Obestatin与Hcy、hs-CRP、Fg、TC、TG、LDL、Lp(a)呈正相关,与HDL呈负相关。结论 CHD患者血清Obestatin水平显著升高,推测Obestatin可能是CHD的一个危险因子。Objective To investigate the correlation between levels of obestatin and coronary atherosclerotic heart dis- ease（CHD）. Methods Selected coronary angiography confirmed 90 cases of CHD patients （observation group）, selected in the same period in the center of the medical examination of healthy people 60 cases （control group）. Detected con- centrations of serum obestatin, homoeysteine （Hcy）, hypersensitive C-reactive protein （hs-CRP）, fibrinogen （Fg） and other indicators, explored the relationship between obestatin and CHD. Results Obestatin levels of patients in the ob- servation group were significantly higher than the control group （P 〈 0.01）. Obestatin and Hcy, hs-CRP, Fg, TC, TG, LDL, Lp （a） were positively correlated, negatively correlated with HDL. Conclusion CHD patients have significantly higher serum levels of obestatin, it suggests that obestatin may be a risk factor for CHD.

关 键 词：OBESTATIN HCY 冠状动脉粥样硬化心脏病 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]