质谱技术在感染性疾病诊断中的应用进展  

Application progress of mass spectrometry in the diagnosis of infectious disease

作　　者：杭亚平[1] 胡龙华[1] 王小中[1] 

机构地区：[1]南昌大学第二附属医院检验科,江西南昌330006

出　　处：《实验与检验医学》2014年第1期1-4,共4页Experimental and Laboratory Medicine

基　　金：江西省自然科学基金项目(编号:20132BAB205062)

摘　　要：质谱(mass spectrometry,MS)技术,尤其是基质辅助激光解吸电离飞行时间质谱(matrix assisted laser desorption/ionization time of flight mass spectrometry,MALDI-TOF MS),具有简便、快速及特异地分析微生物生物大分子标记物质谱图,从而实现临床微生物检验中细菌、真菌及病毒在属、种、株水平上的鉴定。MS在菌血症、尿路感染、毒素检测及耐药监测方面显示出巨大的优势,有望成为临床微生物实验室感染性疾病常用诊断方法。Mass-spectrometric techniques, especially the matrix assisted laser desorption/ionization time of flight mass spec-trometry （MALDI-TOF MS） analyze the mass spectrum of the biomarkers of microorganism conveniently, rapidly and distinctly , demonstrating the identification of bacteria and fungus at level of genus,species and strain. In bacteremia, urinary tract infections, toxin detection and drug resistance monitoring,MS shows great advantage, making it commonly-used diagnostic method of infec-tious diseases for clinical microbiology laboratory hopefully.

关 键 词：微生物鉴定 感染性疾病 应用进展 

分 类 号：R446[医药卫生—诊断学]