硫辛酸联合缬沙坦治疗早期糖尿病肾病的疗效及其对氧化应激的影响  

Effect of lipoic acid combined with valsartan in the treatment of early diabetic nephropathy and its influence on oxidative stress

作　　者：火焱 陈德志[1] 王昭玲[1] 

机构地区：[1]徐州市第一人民医院内分泌科,江苏省徐州221002

出　　处：《中国基层医药》2014年第4期489-491,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：江苏省徐州市卫生局医学科研项目（XWJ2011009）

摘　　要：目的观察硫辛酸联合缬沙坦对早期糖尿病肾病的疗效及对其氧化应激的影响。方法将120例早期糖尿病肾病患者按数字表法随机分成两组，每组60例。A组予缬沙坦80m∥次、每天1次口服；B组予缬沙坦80mg／次、每天1次口服，同时予硫辛酸每天600mg静脉滴注治疗。两组疗程均为2周。比较两组治疗前后24h尿微量白蛋白排泄率（24hUAER）、血清超氧化物歧化酶（SOD）、血清丙二醛（MDA）、血清谷胱甘肽过氧化物酶（GSH-PX）、总抗氧化能力（T—AOC）。结果治疗前A组24hUAER、SOD、MDA、GSH．PX、T．AOC分另U为（153．354-12．78）mg／d、（82．24±10．23）U／mL、（5．02±0．24）μmol／L、（71．58±9．22）U、（7．254-1．26）U／mL，治疗后分别为（128．85±11．62）mg／d、（83．04±10．36）U／mL、（4．98±0．23）I^mol／L、（72．24±9．18）U、（7．29±1．32）U／mL，其中治疗前后24hUAER差异有统计学意义（￡=2．285，P〈0．05）。治疗前B组24hUAER、SOD、MDA、GSH—PX、T-AOC分别为（153．18±12．65）mg／d、（82．25±10．24）U／mL、（5．0l-t-O．24）txmol／L、（71．60±9．21）U、（7．25±1．22）U／mL，治疗后分别为（106．54±10．82）mg／d、（91．35±11．53）U／mL、（4．21±0．18）izmol／L、（80．25±9．88）U、（8．76±1．70）U／mL，治疗前后差异均有统计学意义（t=2．757、2．523、2．748、2．652、2．644，均P〈0．05）。治疗后B组24hUAER、SOD、MDA、GSH—PX、T．AOC与A组差异均有统计学意义（t=2．417、2．444、2．633、2．579、2．525，均P〈0．05）。结论硫辛酸联合缬沙坦可有效治疗早期糖尿病肾病，下调其氧化应激水平，效果优于单独应用缬沙坦。Objective To investigate the effect of lipoic acid combined with valsartan in the treatment of early diabetic nephropathy and its influence on oxidative stress. Methods According to the digital table, 120 patients with early diabetic nephropathy were divided randomly into two groups, each group had 60 cases. The group A and group＇ B were all treated with valsartan,80mg/time, 1 time daily. Meanwhile, the group B was treated with ]ipoic acid, 600rag/time, 1 time a day. Both two groups were treated for 2 weeks. The 24h urinary albumin excretion rate （24h UAER） , serum superoxide dismutase （SOD） , malondialdehyde （MDA） , serum glutathione peroxidase （GSH-PX） , total antioxidant capacity （T-AOC） were measured and compared before and after treatment. Results Before treatment,24h UAER, SOD, MDA, GSH-PX, T-AOC of group A were （ 153.35 ± 12.78） mg/d, （ 82.24 ± 10.23 ） U/mL, （5.02 ± 0.24） μmol/L, （71.58 ± 9.22） U, （7.25 ±1.26） U/mL, and those in group A after treatment were （ 128.85 ± 11.62 ） mg/d, （ 83.04 ± 10.36 ） U/mL, （4.98 ±0.23 ） ~mol/L, （ 72.24 ± 9.18 ） U, （ 7.29 ±1.32 ） U/mL, the differ- ence of 24h UAER was statistically significant （ t = 2. 285, P 〈 0.05 ）. Before treatment,24h UAER, SOD, MDA, GSH- PX,T-AOC of group B were （ 153.18 ±12.65 ） mg/d, （82.25 ±10.24） U/mL, （5.01 ±0.24） μmol/L, （71.60 ± 9.21 ） U, （7.25 ± 1.22） U/mL, and those in group B after treatment were （ 106.54 ± 10.82） mg/d, （91.35 ± 11.53） U/ mL, （4.21 ± 0.18 ） μmol/L, （ 80.25 ± 9.88 ） U, （ 8.76 ± 1.70） U/mL, the differences of them were statistically sig- nificant （ t = 2. 757,2. 523,2. 748,2. 652,2. 644, all P 〈 0.05 ）. Meanwhile, after treatment, the differences of 24h UAER,SOD, MDA, GSH-PX,T-AOC between group A and group B were statistically significant （t = 2. 417,2.444,2. 633, 2.579,2. 525, all P 〈 0.05 ）. Conclusion Lipoic acid combined with valsartan is effective in the treatment of early diabetic

关 键 词：糖尿病肾病 硫辛酸 缬沙坦 

分 类 号：R587.2[医药卫生—内分泌]