芳(杂)环甾体化合物的合成及生理活性研究  

Synthesis and Biological Activity of Steroids Bearing Aromatic Rings and Heterocycles

作　　者：崔建国[1] 刘亮[1] 甘春芳[1] 肖琦[1] 黄燕敏[1] 

机构地区：[1]广西师范学院化学与生命科学学院,南宁530001

出　　处：《化学进展》2014年第2期320-333,共14页Progress in Chemistry

基　　金：广西自然科学基金项目(No.2010GXNSFD013019);广西教育厅自然科学基金重点基金项目(No.201202ZD059)资助~~

摘　　要：芳(杂)环甾体化合物是一类具有显著生理活性的化合物,它们往往具有很好的抗菌、抗炎和抗肿瘤活性。本文根据此类化合物的结构类型进行分类,讨论近年来芳(杂)环甾体化合物的合成及生物活性研究进展,并对其发展趋势和应用前景进行了展望。Steroids bearing aromatic rings and heterocycles are types of compounds with significant physiological activities. Generally, they possess a good antibacterial, anti-inflammatory and anti-tumor activity. In this paper, the synthesis and biological activity of steroids bearing aromatic rings and heterocycles in recent year are reviewed according to the classification of their structures, such as steroidal heterocycles bonded A-ring, fused A-ring, bonded B-ring, bonded D-ring, etc. Their developing trends and applying prospects are also expected.

关 键 词：芳(杂)环甾体化合物 生物活性 抗肿瘤活性 

分 类 号：O629.2[理学—有机化学] TQ463[理学—化学]