甲基丙烯酰乙基磺基甜菜碱类聚合物的生物应用  

Biological Application of Sulfobetaine Methacrylate Polymers

作　　者：许利娜[1] 马培培[1] 陈强[1,2,3] 林思聪[1] 沈健[1,3] 

机构地区：[1]南京大学化学化工学院,南京210093 [2]南京大学常州高新技术研究院,常州213164 [3]江苏省生物医药协同创新中心,南京210093

出　　处：《化学进展》2014年第2期366-374,共9页Progress in Chemistry

基　　金：国家高技术发展计划(863)项目(No.2006AA03Z445);江苏省生物医药协同创新项目资助~~

摘　　要：两性离子聚合物具有阴阳离子基团,能够高度水化,具有优异的生物相容性。甲基丙烯酰乙基磺基甜菜碱(SBMA)聚合物因其独特的两性离子链结构,具有抗蛋白质污染、抗细菌黏附及抗凝血等抗生物污染性能,这种特性使其在生物医学等相关领域得到越来越多的应用。本文介绍了其抗生物污染的水化理论,对甲基丙烯酰乙基磺基甜菜碱类聚合物的结构、性质、合成方法及表面构建方法等作了概述和分析,对其在人造器官材料、组织工程、生物分离、生物监测、温度敏感材料等方面的应用作了重点介绍,并分析了目前应用存在的问题和潜在的应用前景。Zwitterionic polymers have anion and hydrated and render them unique biocompatibility. cation groups simultaneously, which make them highly Because of their unique zwitterionic pendant-side chain structures, sulfobetaine methacrylate （SBMA） polymers present the excellent anti-biofouling properties, i.e. the resistance to protein adsorption, the inhibition of bacterial and blood coagulation, which make them increasingly applied in a wide range of biological and medical related fields recently. The hydration theory, one of the widely accepted antifouling mechanisms, is briefly introduced. In this article, recent progress in the properties, synthesis methods and surface construction methods is reviewed, the applications of SBMA polymers in the materials for artificial organs, tissue engineering, biological separation, bio-rnonitoring system and temperature-sensitive materials are summarized. In addition, SBMA polymers holding great potential for use in biomaterials and issues existed in these applications are also discussed.

关 键 词：生物材料 生物相容性 磺基甜菜碱 

分 类 号：O631[理学—高分子化学] Q813.1[理学—化学]