利伐沙班预防股骨颈骨折关节置换术后血栓的临床观察  

Clinical Observation The Prevention of Femoral neck Fracture Arthroplasty Postoperative Thrombosis with Rivaroxaban

作　　者：童立苗[1] 张显 

机构地区：[1]江苏常州市解放军第102医院,常州213003 [2]江苏江阴市璜土医院,江阴214445

出　　处：《血栓与止血学》2014年第1期20-22,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的观察利伐沙班预防股骨颈骨折关节置换术后血栓的临床效果。方法选取2010年9月至2013年2月来我院就诊的股骨颈骨折实行关节置换术的患者120例,将其随机分为实验组和对照组。实验组在实施关节置换术后口服利伐沙班用来预防血栓的形成,对照组术后进行皮下注射低相对分子质量肝素钠治疗,疗程均为2周。观察两组患者在治疗两周后血栓形成情况。结果治疗后,实验组发生血栓的有5例,对照组有11例,实验组血栓发生率(8.3%)明显小于对照组血栓发生率(18.3%),差异显著具有统计学意义(P<0.05);而两组患者术后第3、9天血小板计数和血红蛋白相比,差异无统计学意义(P>0.05).结论利伐沙班能够显著降低股骨颈骨折实施关节置换后血栓的形成。Objective To observe clinical effects of rivaroxaban prevention of femoral neck fracture ar- throplasty postoperative thrombosis. Methods Select from September 2010 to February 2013 arthroplasty fem- oral neck fracture implement our hospital 120 patients were randomly divided into experimental and control groups. Experimental group in the implementation of joint replacement surgery oral rivaroxaban to prevent the formation of blood clots, the control group after subcutaneous low molecular weight heparin therapy, treatment lasted 2 weeks. Were observed after two weeks of treatment thrombosis. Results After treatment, the experi- mental group thrombotic five cases, eleven cases in the control group, the experimental group, the incidence of thrombosis （8.3 % ） was significantly less than the control group, the incidence of thrombosis （ 18.3 % ） , the difference was statistically significant （ P 〈0. 05 ） ; But the 3,9 days platelet count and emoglobin of two group,without significant differenee（ P 〉0. 05 ）. Conclusion Rivaroxaban significantly reduced femoral neek fraeture in the implementation of the formation of blood elots after joint replaeement.

关 键 词：利伐沙班 股骨颈骨折 关节置换 血栓 

分 类 号：R683.42[医药卫生—骨科学]