血浆D二聚体水平在心血管疾病中应用价值的探讨  

The Application Value of Plasma D-Dimer Level in Cardiovascular Diseases

作　　者：李广华[1] 龚彩平[1] 叶联珍[1] 黄美群[1] 郑洪[1] 来金欣 刘志芳[1] 

机构地区：[1]广东省人民医院,广东省医学科学院检验科,广州510080

出　　处：《血栓与止血学》2014年第1期29-32,共4页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的定量检测血浆中D二聚体(D-dimer,D-D)的水平,研究其在急性/非急性心血管系统疾病中的差异,从而了解其在心血管系统疾病中的诊断价值。方法对2012年6月至2012年11月在我院就诊252例心血管患者的血浆D-D水平进行了检测,分析比较不同疾病血浆D-D的差异性,同时为辨别急性/非急性心血管疾病寻找最佳的临界值。结果急性心血管疾病组D-D升高明显高于非急性心血管疾病组(χ2=31.942,P<0.001),且ROC曲线分析结果提示D-D在755μg/L具有较好的判别意义(AUC=0.709,P<0.001)。结论测定患者血浆中的D-D水平,可以作为心血管疾病患者,尤其是急性心血管病患者纤溶亢进的指标,同时有助于判断病情严重程度和预后。Objective Quantitative determination of plasma D- dimer （ D-dimer, D- D） level to study the differences in the acute / non-acute cardiovascular diseases,to understand the value of the diagnosis of cardio- vascular diseases. Method June 2012 to November 2012 in our hospital for treatment of 258 cases of patients with cardiovascular plasma D-D levels were detected, and comparing different diseases of the differences be- tween plasma D-D,at the same time looking for the best threshold to distinguish between acute / non-acute cardiovascular diseases. Results Acute cardiovascular diseases elevated D-D were significantly higher than the non-acute cardiovascular diseases group （X2 = 31. 942, P 〈 0. 001 ） , and the ROC curve analysis showed that D-D cutoff point 755μg / L has good judgment significance（AUC =0. 709,P 〈0. 001 ）. Conclusion Determination of D-D levels in the plasma of patients, can be used as cardiovascular diseases, especially acute cardiovascular diseases the hyperfibrinolysis indicators, while helping to speculate that the disease severity and prognosis.

关 键 词：D二聚体 心血管疾病 急性 非急性 

分 类 号：R446[医药卫生—诊断学]