脂肪乳液中物质浓度的光学低相干干涉测量  

Optical Low Coherent Interference Measurement of Concentration of Fat Suspension

作　　者：林林[1] 张梅[2] 罗云瀚[3] 

机构地区：[1]广东医学院信息工程学院,东莞523808 [2]东莞理工学院电子工程学院,东莞523808 [3]暨南大学理工学院,广州510632

出　　处：《纳米技术与精密工程》2014年第2期117-121,共5页Nanotechnology and Precision Engineering

基　　金：国家自然科学基金资助项目(61008057);东莞市科技计划资助项目(2012108102001;2012108102006)

摘　　要：为了实现对散射介质的非接触测量，有效地提高灵敏度，提出了光学低相千干涉测量方法．采用光纤型迈克尔逊干涉结构，增加了扫描延迟线和光学外差探测电路，实现了具有光程分辨能力的干涉测量．以脂肪乳剂Intralipid为样本，通过稀释和加入染色剂的方法改变其散射和吸收特性．通过对溶液内反射信号的干涉测量和曲线拟合，研究了光程相关的干涉光信号与物质浓度的依赖关系．实验对象为散射和吸收特性相对稳定的脂肪乳剂和印度墨水混合物，其中Intralipid乳剂浓度在4％～16％之间，印度墨水浓度在0—1％之间．拟合方法引用了广义惠更斯菲涅耳（EHF）模型的解析表达式，拟合相关系数在0．98以上．实验结果与积分球测量结果进行了比较，初步验证了理论方法的可行性。In order to enhance sensitivity, optical low coherent interference method was applied in nonin- vasive measurement of scattering media. The experimental structure is based on fiber Michelson interfer- ometer equipped with scanning optical delay line and heterodyne detection circuit, to realize the optical path resolving coherent interference measurement. The samples are the mixture of fat suspension and bio- logical stain that the scattering and absorption coefficients can be adjusted accurately. Through interfer- ence measurement of reflected optical signal and conic fitting, the relationship between coherent signal and solute concentration was analyzed. The samples are the mixture of Intralipid with the concentration of 4%--16% , and India ink with the concentration of 0--1% ,which both have stable optical characteris- tics. Extended Huygens-Fresnel（EHF） principle was adopted to data fitting and reconstruction of optical parameters. The correlation coefficients of linear and conic fitting are higher than 0.98. The experiment result has been compared with data from integrating sphere to provide preliminary proof for this method.

关 键 词：非接触测量 广义惠更斯菲涅耳原理 光学低相干干涉测量 光程分辨 

分 类 号：R318.51[医药卫生—生物医学工程]