影响对乙酰氨基酚用药因素的探讨  

Exploration of Influential Factors on Acetaminophen Medication

作　　者：李春福[1] 李燕[1] 李懂[1] 周建友[1] 李仲娟[1,2] 

机构地区：[1]湖北理工学院医学院,湖北黄石435003 [2]黄石市中心医院,湖北黄石435000

出　　处：《湖北理工学院学报》2014年第1期62-64,共3页Journal of Hubei Polytechnic University

基　　金：湖北理工学院大学生科技创新项目(项目编号:12cx40);湖北理工学院创新团队项目(项目编号:201225);湖北省重点培育学科湖北理工学院药学学科资助

摘　　要：通过改变对乙酰氨基酚的给药途径和联合用药方式,探讨对乙酰氨基酚的临床合理用药。采用比色法测不同时间点的血药浓度,己糖激酶-UV法测定血液中血糖浓度。结果为:不同给药方式中,口服对乙酰氨基酚吸收快、血药浓度维持时间长;联合用药(蛋氨酸、多糖)影响血糖值,蛋氨酸在注射1 h后血糖值会升高,多糖则在注射2 h后升高血糖。口服对乙酰氨基酚适合任何患者;肌注对乙酰氨基酚适合糖尿病患者;保肝类药物不适合与对乙酰氨基酚联合使用。Objective：to discuss the rationality of the use of acetaminophen by changing the delivery and the drug combination.Method：The plasma concentrations in different time point were determined by colorimet-ric;Blood glucose levels was determined by Hexokinase -UV method.Result：Acetaminophen taken by mouth absorbs quickly and could produce a high blood drug concentration for a long time;The impact of combination （ with methionine or with polysaccharide ） on blood glucose level was observed .Blood sugar increase was showed at 1 hour after injecting methionine ,and at 2 hours after injecting polysaccharide .Conclusion：Oral ac-etaminophen is suitable for general patients;intramuscular injection acetaminophen is suitable for diabetics;Hepatoprotectants are not appropriate for the drug combination .

关 键 词：蛋氨酸 多糖 对乙酰氨基酚 比色法 葡萄糖氧化法 

分 类 号：R969.1[医药卫生—药理学]