头孢呋辛与阿奇霉素治疗慢性鼻窦炎的临床疗效对比研究  

Clinical efficacies of cefuroxime and azithromycin in treatment of chronic sinusitis

作　　者：马玉茹 刘秀平 王士杰 

机构地区：[1]中国航天科工集团731医院耳鼻喉科,北京100074

出　　处：《中华医院感染学杂志》2014年第5期1136-1137,1143,共3页Chinese Journal of Nosocomiology

基　　金：十一五国家科技支撑计划基金资助项目(2006BAI104A01);北京市科技计划重大基金项目(H020920010491)

摘　　要：目的研究头孢呋辛与阿奇霉素治疗慢性鼻窦炎的临床疗效，以期指导临床合理用药。方法选取临床186例慢性鼻窦炎患者，均于围手术期应用抗菌药物，术前使用3～7d，术后最长使用6个月，术后一周以内均静脉滴注抗菌药物；186例患者随机分为两组，阿奇霉素组应用阿奇霉素0．5g每日1次，头孢呋辛组应用头孢呋辛1．5g每日2次；与治疗后2、4、6周对两组治疗效果进行比较分析，采用SPSS13．0软件进行数据处理，资料比较采用y。检验，计量资料间比较采用t检验，P〈0．05为差异有统计学意义。结果治疗两周后总有效率阿奇霉素组20．7％、头孢呋辛组23．4％，两组患者的总有效率差异无统计学意义；治疗4周后总有效率阿奇霉素组30．4％、头孢呋辛组56．4％，治疗6周后总有效率阿奇霉素组51．1％、头孢呋辛组72．3o／4，两组患者的治疗4、6周总有效率差异有统计学意义（P〈0．05），且头孢呋辛组的有效率明显高于阿奇霉素组。结论头孢呋辛用于治疗慢性鼻窦炎的临床疗效优于阿奇霉素，头孢呋辛应作为首选抗菌药物治疗慢性鼻窦炎，在临床进行推广。OBJECTIVE To study the clinical efficacies of azithromycin and cefuroxime in treatment of chronic sinusitis so as to provide guidance for reasonable clinical use of antibiotics. METHODS A total of 186 patients with chronic sinusitis were enrolled in the study, all the subjects used antibiotics during perioperative period, with 3-7 days before surgery, half a year after surgery, and all the subjects received the intravenous administration of antibiotics one week after surgery; the 186 patients were randomly divided into two groups, the azithromycin group was treated with o. 5g azithromycin, once per day. while the cefuroxime group was given 1. 5g cefuroxime , twice per day; then the therapeutic effect was compared after the treatment for 2. 4. and 6 weeks; the data were processed with the use of SPSS13. 0 software. the chi-square test was conducted for comparison of data. the t-test was performed for comparison of count data. and P〈O. 05 was defined as statistical significance. RESULTS Two weeks after the treatment. the total effective rate of treatment was 20. 7 % in the azithromycin group. 23. 4 % in the cefuroxime group. the difference in the total effective rate between the two groups was not statistically significant; four weeks after the treatment. the total effective rate of treatment was 30. 4 % in the azithromycin group. 56. 4 % in the cefuroxime group; six weeks after the treatment. the total effective rate of treatment was 51. 1 % in the azithromycin group. 72.3% in the cefuroxime group. with statistical significance （ P〈 0. 05）; furthermore. the effective rate of the cefuroxime group was significantly higher than that of the azithromycin group. CONCLUSION Cefuroxime is superior to azithromycin in the clinical efficacy in treatment of chronic sinusitis. and cefuroxime should be used as the preferred antibiotic for treatment of chronic sinusitis. which is worthy to be promoted in the hospital.

关 键 词：头孢呋辛 阿奇霉素 慢性鼻窦炎 临床疗效 

分 类 号：R978.1[医药卫生—药品]