幽门螺杆菌感染与荨麻疹的相关性研究  

Correlation between Helicobacter pylori infection and urticaria

作　　者：尚念秀[1] 亓秀丽[1] 

机构地区：[1]莱芜市人民医院皮肤科,山东莱芜271100

出　　处：《中华医院感染学杂志》2014年第5期1197-1198,1203,共3页Chinese Journal of Nosocomiology

基　　金：莱芜市科研基金资助项目(鉴字2005-043)

摘　　要：目的研究荨麻疹与幽门螺杆菌(Hp)感染的相关性并分析相关的预防措施,为降低临床荨麻疹患者感染幽门螺杆菌提供参考资料。方法选取2010年1月-2012年9月门诊治疗的荨麻疹患者120例,并随机选取同期体检的正常人群120名,对两组进行血清抗Hp-IgG抗体检测,观察两组患者Hp阳性情况,将80例荨麻疹Hp阳性患者随机分为试验组43例和对照组37人,对照组患者应用常规荨麻疹治疗,试验组患者在对照组基础上应用三联疗法(阿莫西林+克拉霉素+奥美拉唑),观察并对比试验组与对照组的疗效。结果荨麻疹组Hp阳性80例占66.67%,正常组Hp阳性44人占36.67%;经治疗后,试验组的Hp转阴率达86.05%,对照组Hp转阴率达到70.27%;试验组显效8例,好转17例,总有效率为86.05%;对照组显效3例,好转7例,总有效率78.38%;上述数据差异均有统计学意义(P<0.05)。结论慢性荨麻疹与Hp的感染有相关性,预防措施主要针对过敏原进行,有效降低感染率。OBJECTIVE To study the correlation between the hives and the Helicobacter pylori （Hp） infection and put forward corresponding prevention measures so as to reduce the incidence of Hp infection in the patients with hives. METHODS Totally 120 cases of urticaria. who were treated in the outpatient department from Jan 2010 to Sep 2012. were enrolled in the study. meanwhile 120 healthy people were recruited. then the serum HP-IgG antibody was tested. the positive rates of Hp of the two groups of patients were observed; totally 80 urticaria patients with positive Hp were randomly divided into the experimental group with 43 cases and the control group with 37 cases; the patients in the control group were treated with conventional method. while the patients in the experimental group were treated with triple therapy （orneprazole plus amoxicillin plus clarithromycin） based on the treatment of the control group. and the clinical efficacy was observed and compared between the experimental group and the control group. RESULTS There were 80 （66. 67 %） cases with Hp tested positive in the urticaria group and 44 （36.67%） in the normal group; after the treatment. the negative conversion rate of Hp was 86. 05% in the experimental group. 70. 27 % in the control group. There were 8 cases effective and 17 cases improved in the experimental group with the total effective rate of 86. 05 % and 3 cases effective and 7 cases improved in the control group with the total effective rate of 78. 38%. with statistical significance in all the above data （P〈0. 05）. CONCLUSION There is correlation between the chronic urticaria and the Hp infection; the prevention measures should be taken by aiming at the allergen so as to effectively reduce the infection rate.

关 键 词：荨麻疹 幽门螺杆菌 相关性 护理对策 

分 类 号：R181.32[医药卫生—流行病学]