新型5,6-2H-Lamellarinη及其类似物全合成研究  

Synthesis of Novel 5,6-2H-Lamellarin η and Analogues

作　　者：王爱玲[1,2] 郑学良[1,3] 赵壮志[1,3] 李长平[1] 陶波[2] 郑学仿[1,3] 

机构地区：[1]大连大学环境与化学工程学院,大连116622 [2]东北农业大学农学院,哈尔滨150030 [3]大连大学辽宁省生物有机化学重点实验室,大连116622

出　　处：《有机化学》2014年第2期429-433,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21271036);大连市优秀青年科技人才基金(No.2009J22DW038)资助项目~~

摘　　要：以2,4-二异丙氧基-α-溴代苯乙酮类化合物1a,1b和异喹啉类化合物1c为原料,通过"Knorr缩合-酯化-关环"的方法,成功地合成目标化合物5,6-2H-Lamellarinη(5a)及其类似物5b,同时得到了两种新型的开链Lamellarin(化合物I、II).本研究共合成10种化合物,其中6种为新化合物,其结构通过1H NMR,13C NMR,MS,IR,HRMS谱图手段进行了表征.According to the reaction of ＂Knorr condensation-esterification-cyclization＂, the target compounds, 6-2H- lamellarin rI （5a） and analogues 5b were synthesized successfully from 2,4-diisopropoxy-a-bromo-acetophenone compounds la, lb and the isoquinoline compound lc. Two kinds of novel open-chain lamellarins （compounds I, II） were accompanied to obtain during the synthesis of 5a. In this paper, ten compounds had been got including six new compounds, which are identified by lH NMR, 13C NMR, MS, IR, HRMS techniques.

关 键 词：5 6-2H-Lamellarin 11 合成 Knorr缩合 

分 类 号：O629.3[理学—有机化学]