腰椎间盘突出症患者温针治疗前后血清CGRP及IL-1α的变化及临床意义  

Changes and clinical significance of CGRP and IL-1αbefore and after warm acupuncture therapy in patients with lumbar disc herniation

作　　者：冯新国[1] 李小斌[1] 易建良[2] 杨帆[2] 刘晓敏[3] 

机构地区：[1]长沙医学院附属株洲市三三一医院检验科,湖南株洲412001 [2]长沙医学院附属株洲市三三一医院脊柱外科,湖南株洲412001 [3]湖南中医药高等专科学校,湖南株洲412001

出　　处：《国际检验医学杂志》2014年第5期521-522,共2页International Journal of Laboratory Medicine

基　　金：2011年度湖南省中医药科研计划项目(201188)

摘　　要：目的探讨降钙素基因相关肽(CGRP)及白细胞介素1α(IL-1α)在温针治疗腰椎间盘突出症患者前后血清中的变化及临床意义。方法用酶联免疫吸附测定(ELISA)法检测计入统计的60例腰椎间盘突出症患者在温针治疗前后血清及15例健康对照组血清CGRP及IL-1α水平。观察腰椎间盘突出症患者温针治疗前后McGill疼痛量表各项评分及血CGRP、IL-1α水平变化情况。结果腰椎间盘突出症患者针灸治疗后McGill疼痛量表各项评分均明显下降,差异有统计学意义(P<0.01),血清CGRP及IL-1α水平明显降低,差异有统计学意义(P<0.01)。结论 CGRP及IL-1α可以作为针灸治疗腰椎间盘突出症疗效观察指标,为治疗腰椎间盘突出症保守疗法提供依据。Objective To investigate the changes and clinical significance of calcitonin gene related peptide （CGRP） and interleu-kin 1α（IL-1α） before and after warm acupuncture therapy in the patients with lumbar disc herniation （LDH ） .Methods Serum CGRP and IL-1αcontents were detected before and after the warm acupuncture therapy in 60 cases of lumbar disc herniation and 15 healthy control cases by ELISA method for conducting the statistical analysis .The changes of the McGill pain scores and serum CGRP and IL-1αconcentrations before and after the warm acupuncture therapy were observed .Results The McGill pain scores af-ter the warm acupuncture therapy in the LDH patients were significantly decreased ,the difference was statistically significant （P＆lt;0 .01） ,and serum CGRP and IL-1α concentrations were significantly decreased ,the difference was statistically significant （P＆lt;0 .01） .Conclusion CGRP and IL-1αcan be used as the observation index of the effects for the warm acupuncture therapy in trea-ting LDH ,which can provide the basis for the conservative treatment of LDH .

关 键 词：酶联免疫吸附测定 降钙素基因相关肽 白细胞介素1Α INTERLEUKIN 1α 

分 类 号：R446.6[医药卫生—诊断学] R681.53[医药卫生—临床医学]