TORCH感染孕妇IgG亲和力检测的临床价值  

The clinical value of IgG antibodies avidity index detection in pregnant women with TORCH infection

作　　者：吴冬生[1] 吴元健[1] 任雅璐 王榴红[1] 

机构地区：[1]南京医科大学附属苏州市立医院本部检验科,江苏苏州215002 [2]苏州大学附属第一医院检验科,江苏苏州212002

出　　处：《国际检验医学杂志》2014年第5期538-539,共2页International Journal of Laboratory Medicine

基　　金：苏州市科技计划项目(SZD09128)

摘　　要：目的通过检测TORCH感染孕妇IgG亲和力指数(AI),探讨TORCH感染类型与妊娠结局间关系。方法收集TORCH各型病原体IgM阳性孕妇血清,检测其IgG亲和力指数(AI),并追踪妊娠结局。结果在TORCH各病原体近期感染的孕妇中,HSV(含1型及2型)、RUB、CMV、TOXO原发感染(AI<30%)的比例分别为0、3.8%、9.3%、7.9%;在CMV原发感染的10例孕妇中,2例妊娠结局异常(稽留流产),CMV疑似原发感染孕妇中发现1例为异常妊娠;TOXO原发感染孕妇发现1例为胎儿畸形(脑积水),其余均为正常妊娠。结论在TORCH各病原体近期感染的孕妇中,以非原发性感染为主;而巨细胞及弓形虫原发感染对胎儿的侵害则远大于非原发感染。Objective To explore the relationship between the type of TORCH infection and pregnancy outcome through the de-tection of TORCH infection in pregnant women with IgG avidity index （AI） .Methods Collected each type of TORCH pathogens IgM positive maternal serum ,and detect the IgG avidity index and track the outcome of pregnancy .Results The rate of TORCH pathogens recent infection （AI＆lt;30% ）in pregnant women ,HSV ,RUB ,CMV ,TOXO respectively were 0 ,3 .8% ,9 .3% ,7 .9% ;In the group of pregnant women with TORCH-IgG AI＆lt;30% ,there were 2 cases of pregnancy outcome of abnormal （missed abortion） and one case of fetal malformations （hydrocephalus） .Conclusion In the recent infection of TORCH pathogens in pregnant women , mainly are non-primary infection ;The damage of cytomegalovirus and Toxoplasma gondii primary infection to the fetus is much larger than the non-primary infection .

关 键 词：人类优生优育病毒 微阵列酶联免疫法 孕妇 

分 类 号：R446.1[医药卫生—诊断学]