补肾清透方对慢性乙肝HBeAg阳性患者血清IL-2、IL-4、IL-10、TNF-α及IFN-γ的影响  

Influence of Bushenqingtou Decoction on serum IL-2,IL-4,IL-10,TNF-αand IFN-γ in chronic hepatitis B patients with positive HBeAg

作　　者：刘心亮[1] 熊益群[1] 周大桥[1] 童光东[1] 贺劲松[1] 张晓晖[1] 徐绍钢[1] 穆桂萍[1] 刘文赫[1] 

机构地区：[1]广州中医药大学附属深圳医院中心实验室肝病科,广东深圳518033

出　　处：《国际检验医学杂志》2014年第5期565-566,571,共3页International Journal of Laboratory Medicine

基　　金：2011年深圳市科技计划资助项目(201103387)

摘　　要：目的观察补肾清透方治疗慢性乙型肝炎(CHB)乙型肝炎e抗原(HBeAg)阳性患者外周血中白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、肿瘤坏死因子α(TNF-α)和干扰素-γ(IFN-γ)的变化。方法 60例CHB HBeAg阳性患者被随机分成治疗组和对照组,每组30例,CHB治疗组接受补肾清透方治疗,疗程48周,CHB对照组不接受药物治疗。分别在开始和第48周时两组患者抽血检测HBV DNA、IL-2、IL-4、IL-10、TNF-α和IFN-γ。结果 CHB治疗组治疗后与治疗前比较,IL-2、TNF-α、IFN-γ明显升高,HBV DNA、IL-4、IL-10明显下降(P<0.01);CHB对照组治疗前、后各项指标比较,差异无统计学意义(P>0.05)。结论补肾清透方能抑制CHB HBeAg阳性患者HBV DNA复制,可提高机体的细胞免疫功能。Objective To observe the changes of peripheral blood interleukin-2（IL-2） ,interleukin-4（IL-4） ,interleukin-10（IL-10） ,tumor necrosis factor-alpha（TNF-α） and interferon gamma （IFN-γ） in chronic hepatitis B（CHB） patients with positive e-anti-gen（HBeAg） treated by Bushenqingtou Decoction .Methods 60 cases of CHB with positive HBeAg were randomly divided into the treatment group and the control group ,30 cases in each group .The CHB treatment group received Bushenqingtou Decoction with the treatment course of 48 week ,while the CHB control group did not received the medication therapy .In the beginning and at 48 weeks of treatment ,the blood in the two CHB groups were collected for detecting HBV DNA ,IL-2 ,IL-4 ,IL-10 ,TNF-αand IFN-γ. Results Compared with before treatments ,the levels of IL-2 ,TNF-αand IFN-γafter treatments in the CHB treatment group were obviously increased ,while the levels of HBV DNA ,IL-4 and IL-10 were remarkably decreased （P＆lt;0 .01）;however ,there were no statistical differences of the various indexes after the treatments in the CHB control group （P＆gt;0 .05） .Conclusion Bushenqingtou Decoction could inhibit the replication of HBV DNA in the CHB patients with positive HBeAg and improve the body immune func-tion .

关 键 词：补肾清透方 肝炎  乙型  慢性 细胞因子类 

分 类 号：R512.62[医药卫生—内科学]