小气道功能测定在慢性阻塞性肺疾病中的临床应用  

CLINICAL APPLICATION OF SMALL AIRWAY FUNCTION ASSAY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

作　　者：张二明[1] 赵春燕[1] 王艳[1] 孙佳[1] 向平超[1] 

机构地区：[1]北京大学首钢医院呼吸科,北京100144

出　　处：《齐鲁医学杂志》2014年第1期54-55,共2页Medical Journal of Qilu

摘　　要：目的 探讨流量-容积曲线中小气道功能检测在慢性阻塞性肺疾病（COP D）中应用意义。方法对COPD病人220例、吸烟无症状病人160例和220例健康体检者行肺功能测试,比较3组一秒率（FEV1/F VC）及剩50%肺活量时的用力呼气流速（MEF50）、剩25%肺活量时的用力呼气流速（MEF25）以及中段呼气流速（MEF25-75）。结果 吸烟无症状组小气道指标MEF50、MEF25、MEF25-75与健康体检组比较均明显降低,COPD组F EV1/F VC、MEF50、MEF25、MEF25-75与健康体检组比较均明显降低,差异有显著性（F=34.27～108.24,q=5.87～38.26,P〈0.05）。结论 吸烟者即使无症状也容易发展成为COP D病人。Objective To assess the clinical significance of small airway function assay（SAFA）based on the flow-volume（F-V）curve in chronic obstructive pulmonary disease（COPD）. Methods Pulmonary function tests were performed in 220 COPD patients,160without-symptoms-smokers and 220healthy individuals.The FEV1/FVC,the maximum expiratory flow rate of 50%remaining lung capacity（MEF50）,maximum expiratory flow rate of 25%remaining lung capacity（MEF25）and middle expiratory flow（MEF25-75）were compared between the three groups. Results Compared with the healthy individuals,the MEF50,MEF25,and MEF25-75 in asymptomatic smokers decreased,the differences being significant;the FEV1/FVC,MEF50, MEF25,and MEF25-75 decreased in the COPD group（F=34.27-108.24,q=5.87-38.26,P0.05）. Conclusion Smokers can easily develop COPD even though they have no symptoms.

关 键 词：呼吸功能试验 肺疾病 慢性阻塞性 吸烟 

分 类 号：R563.3[医药卫生—呼吸系统]