γ-干扰素联合抗真菌药物治疗RVVC的临床研究  

Clinical study of γ-interferon combined with antifungal drugs in the treatment of recurrent vulvovaginal candidiasis

作　　者：李翠青[1] 周梅[1] 黄艳萍[1] 

机构地区：[1]深圳市宝安区妇幼保健院,广东深圳518133

出　　处：《中国妇幼健康研究》2014年第1期126-128,共3页Chinese Journal of Woman and Child Health Research

基　　金：2010年深圳市科技计划资助项目(基金编号201003342)

摘　　要：目的探讨γ-干扰素阴道用药治疗复发性外阴阴道假丝酵母菌病（RVVC）的临床效果。方法将2012年12月至2013年7月在深圳市宝安区妇幼保健院妇科门诊就诊的RVVC患者分为两组，研究组45例，口服伊曲康唑200mg，每日2次，共3天，用生理盐水抹洗阴道后，应用γ-干扰素20万IU稀释液涂抹于阴道壁及宫颈阴道部，隔日1次，共4次，每晚放咪康唑栓1枚；对照组45例，每日口服伊曲康唑200mg，每日2次，共3天，每晚放咪康唑栓1枚。对其用药后临床症状改善及治疗情况进行分析。结果停药后第7—14天、1个月、2个月进行3次复查。研究组的治愈率高于对照组，但两组3次复查的总有效率比较差异均无统计学意义（X^2值分别为0．8108、0．7145、1．3572，均P〉0．05）。结论γ-干扰素阴道用药治疗RVVC的疗效有待观察，需要应用比阴道真菌学检测更为敏感、精确的方法方能得出确切的结论。Objective To explore the clinical effect of γ-interferon vaginal medication in the treatment of recurrent vulvovaginal candidiasis （RVVC）. Methods From December 2012 to July 2013 90 cases of RVVC visiting gynecology clinic of Shenzhen City Maternal and Child Health Hospital of Baoan District were divided into observation group （ n = 45 ） and control group （ n = 45 ）. The observation group was given oral itraconazole 200mg, two times a day for 3 days. Meanwhile, physiological saline was used to rinse vagina, and y-interferon 200 000 IU of dilution was used to smear vaginal wall and cervix vagina, 1 time every other day, for 4 times. One miconazole suppository was put every night. The control group got daily oral itraconazole 200mg, two times a day, for 3 days. One miconazole suppository was put every night. The improvement of clinical symptoms after treatment and therapeutic condition were analyzed. Results Three rechecks were performed after medication withdrawal for 7 - 14 days, 1 month and 2 months. The cure rate of the observation group was higher than the control group, but the total effective rate of three rechecks were not significantly different between two groups （X^2 value was 0. 8108, 0. 7145 and 1. 3572, respectively, all P 〉 0.05 ）. Conclusion The effect of y -interferon vaginal medication on RVVC remains to be observed. A method more sensitive and accurate than vaginal mycology is needed to draw further conclusion.

关 键 词：复发性外阴阴道假酵母菌病 伽马干扰素 阴道用药 局部免疫 

分 类 号：R711[医药卫生—妇产科学]