MicroRNAs与细胞分化和早期胚胎发育  

Impact of MicroRNAs on cell differentiation and early embryonic development

作　　者：江胜林[1] 张军强[1] 凌秀凤[1] 

机构地区：[1]南京医科大学附属南京市妇幼保健院生殖医学中心,江苏南京210004

出　　处：《中国妇幼健康研究》2014年第1期165-167,共3页Chinese Journal of Woman and Child Health Research

摘　　要：MicroRNAs（miRNAs，miRs），即小分子RNA，是一类大小约19～25个核苷酸组成的非编码小分子RNA，主要通过特异性抑制靶蛋白翻译或降解靶基因mRNA发挥负性调控基因表达的作用。迄今为止已经成功鉴定了15000多种miRNAs。miRNA不但在细胞的增殖、分化、凋亡等过程中发挥着重要作用，同时也能调控胚胎的早期发育。该文就miRNA相关机制和功能、主要检测方法及其对细胞分化和早期胚胎发育作用的研究现状进行综述。MicroRNAs （miRNAs, miRs） represent a novel class of small endogenous noncoding RNA with 19-25 nucleotides which can negatively regulate gene expression by inhibiting translation of target mRNAs or cleaving target mRNAs. At present, over 15 000 microRNA genes have been identified successfully. MiRNAs have been proved to play an important role in cellular proliferation, differentiation, and apoptosis as well as in embryonic development. This review summarized the mechanism, function and principal methodologies of miRNAs and the current researches on influence of miRNAs on cell differentiation and early embryonic development.

关 键 词：MICRORNAS 细胞分化 早期胚胎发育 植入前胚胎 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]