肾康注射液对血液透析患者残余肾功能的保护作用  

Protective effect of ShenKang injection on residual renal function in hemodialysis patients

作　　者：刘辉辉[1] 刘滇军[1] 王黎萍[1] 李骏峰[1] 

机构地区：[1]湖北医药学院附属人民医院肾病内科,湖北十堰442000

出　　处：《临床内科杂志》2014年第2期110-112,共3页Journal of Clinical Internal Medicine

摘　　要：目的 观察肾康注射液对血液透析患者残余肾功能（RRF）的保护作用.方法 61例血液透析患者随机分为对照组和治疗组,治疗组给予肾康注射液治疗6个月.比较两组患者治疗前、后日均尿量、RRF以及血红蛋白、血白蛋白、三酰甘油、胆固醇、超敏C反应蛋白（hsCRP）、肿瘤坏死因子（TNF）-α水平.结果 治疗前两组患者间日均尿量、RRF及血红蛋白、血白蛋白、三酰甘油、胆固醇、hsCRP和TNF-α间比较差异均无统计学意义;治疗后治疗组血红蛋白、血白蛋白、三酰甘油和胆固醇与对照组比较差异无统计学意义,日均尿量和RRF水平高于对照组,hsCRP和TNF-α水平低于对照组（P＜0.05）.结论 肾康注射液可以保护血液透析患者残余肾功能,其机制可能与减轻患者体内炎症反应有关.Objective To observe protective effect of ShenKang injection on residual renal func- tion（RRF） in hemodialysis patients. Methods Sixty-one hemodialysis patients with uremia were divided into two groups randomly ,with 30 patients in control group and 31 patients in treatment group. Patients in treatment group were treated with ShenKang injection and the therapeutic course were 6 months. Levels of daily urine output, RRF, hemoglobin, blood albumin, triglyeeride, cholesterin, supersensitivity C reactive protein（hsCRP） and tumour necrosis factor-α（TNF-α） were detected before and after treatment in two groups. Results There were no significant differences of levels of daily urine output, RRF, hemoglobin, blood albumin, triglyceride, eholesterin, hsCRP and TNF-c~ before treatment between two groups. After treatment,there were no significant differences of levels of hemoglobin, blood albumin, triglyceride and cholesterin between two groups. Comparison with control group,levels of daily urine output and RRF were increased and levels of blood hsCRP and TNF-α were increased in treatment group. Conclusion Shen- Kang injection could protect residual renal function in hemodialysis patients with possible mechanism of abatement on inflammation.

关 键 词：肾康注射液 血液透析 残余肾功能 炎症反应 

分 类 号：R459.5[医药卫生—治疗学]