精神分裂症患者服用氨磺必利后血药浓度与临床疗效的关系  

Relationship between schizophrenia Blood drug concentration and clinical efficacy in patients with schizophrenia after taking amisulpride

作　　者：蒋平[1] 张新风[1] 邓小鹏[1] 

机构地区：[1]湖北省荆州市精神卫生中心,荆州434000

出　　处：《海峡药学》2014年第2期144-147,共4页Strait Pharmaceutical Journal

摘　　要：目的 探讨氨磺必利对治疗精神分裂症患者血药浓度与临床疗效之间的相关性,从而确定氨磺必利更安全、有效的治疗剂量.方法 对90例单一使用氨磺必利治疗精神分裂症的患者,于治疗前及治疗后2、4、8周采用高效液相色谱法测定血药浓度,同时采用阳性与阴性症状量表（PANSS）、治疗中出现的症状量表（TESS）分别评定疗效和不良反应,并进行相关性分析.结果 加标血浆氨磺必利10、400、100μg·mL-1的日内变化回收率分别为100.18%、97.53%、97.71%,日内、日间差RSD均低于8%（n=6）;相同剂量不同性别、年龄患者的血药浓度无明显统计学意义（P＞0.05）.氨磺必利（1日800～1200mg）治疗2、4、8周后的血药浓度分别为220.39±142.56nmol·L-1、310.24±154.98nmol·L-1和336.36±104.25nmol·L-1.氨磺必利的血浓度与临床疗效有明显的相关性.结论 氨磺必利治疗精神分裂症时,其剂量在1日800～1200mg,血药浓度在220～336nmol·L-1时更安全有效.OBJECTIVE To investigate the correlation between the division of amisulpridein the treatment of schizophrenia serum drug concentration and clinical efficacy,in order to determine the therapeutic dose and amisul- pride will more safe, effective. METHODS 90 cases whose were single given Amisulpride in the treatment of schiz- ophrenia were determined blood drug concentration by HPLC before and after treatment in 2,4,8 weeks, and the pos- itive and negative symptom scale （PANSS）, the Treatment Emergent Symptom Scale （TESS） were adopted to evalu- ate the efficacy and adverse reactions, and the correlation was analysed. RESULTS The changes of recovered plas- ma amisulpride 10,400,100μg .mL-1 days were 100. 18% ,97.53% ,97.71% ,days,between day RSD were less than 8% （n = 6 ） ;blood drug concentration of the same dose of different gender, age of the patients was not statistical- ly significant （ P 〉 0.05 ）. Amisulpride （ 800 - 1200mg .d - 1 ） therapeutic concentrations of 2,4,8 weeks respective- ly 220. 39±142.56nmol . L-1 ,310.24 ± 154.98nmol. L-1 and 336.36 ±104.25nmol . L-1. The blood concentra- tion of amisulpride and will have a positive correlation with the clinical efficacy. CONCLUSION Amisulpride in the treatment of schizophrenia with the dose of 800 ± 1200mg . d- 1 ,the blood drug concentration of 220 ± 336nmol . L-1 is safe and effective.

关 键 词：氨磺必利 血药浓度 高效液相色谱法 疗效 副反应 

分 类 号：R969.4[医药卫生—药理学]