LC-MS/MS技术在药物代谢研究中的应用进展  

Application progress of LC-MS/MS technology in drug metabolism research

作　　者：姜艳彬[1] 单吉浩[1] 王莹[1] 蔡英华[1] 田亚平[1] 

机构地区：[1]中国动物疫病预防控制中心,北京100125

出　　处：《药物分析杂志》2014年第3期385-391,共7页Chinese Journal of Pharmaceutical Analysis

摘　　要：液质联用(LC-MS/MS)分析技术的发展为药物体内代谢产物研究提供了简便、快速的分析方法,应用该技术对药物代谢产物进行分析,一般包括LC-MS/MS谱的数据采集、数据处理、结构鉴定等步骤。本文分别对近几年LC-MS技术在药物代谢研究的数据采集、数据处理、结构鉴定3个方面中的应用进行阐述,为药物代谢的LC-MS研究提供方法和策略。The development of LC - MS/MS technology provides a simple and rapid method for drug metabolites study. The application of this technique generally involves LC - MS/MS data acquisition, data processing and struc- ture identification. This paper reviewed the application of LC - MS technique in drug metabolism studies in respect to three aspects：data acquisition, data processing, and structure identification. This review provides methods and strategies for studies on drug metabolism bv LC - MS.

关 键 词：药物代谢 数据采集 数据处理 结构鉴定 液质联用技术 应用进展 

分 类 号：R917[医药卫生—药物分析学]