复方α-酮酸对慢性肾脏病患者的降压作用研究  

Effect of compound ?-Ketoacid on blood pressure change in patients with chronic kidney disease

作　　者：李松杨[1] 陈松[2] 张正华[3] 马骏[1] 

机构地区：[1]上海静安区中心医院(复旦大学附属华山医院静安分院)肾内科,上海200040 [2]上海静安区中心医院(复旦大学附属华山医院静安分院)老年科,上海200040 [3]上海静安区中心医院(复旦大学附属华山医院静安分院)肿瘤科,上海200040

出　　处：《世界临床药物》2014年第3期151-154,共4页World Clinical Drug

基　　金：上海市卫生局科研课题相关研究;编号2009247

摘　　要：目的评价复方α-酮酸对慢性肾脏病（CKD）患者血压的影响。方法选择CKD3～5期非血液透析伴高血压患者64例，患者均低蛋白饮食，联合复方Ⅱ-酮酸治疗（2．52g／次，一日3次）6个月，比较治疗前后的血压，以及甲状旁腺素（PTH）和。肾功能变化。结果64例患者治疗后收缩压（SBP）和舒张压（DBP）及PTH均显著降低，但血清肌酐和尿素氮治疗前后相比差异无统计学意义。结论CKD患者采用低蛋白饮食加复方α-酮酸治疗对血压控制可能有帮助。Objective Evaluate the impact with compound ct-Ketoacid on blood pressure change in patients with chronic kidney disease （CKD）. Methods Selected 64 patients of CKD 3-5 grade combined with hypertension but without hemodialysis treatment. Patients were given a standard low protein diet E0.6 g/ （kg·d）] and compound α-Ketoacid （2.52g, tid） for six months. A statistic method was used to compare blood pressure, PTH and kidney function changes before and aftr treatment. Results Patients who received compound α-Ketoacid treatment for 6 months, were observed to have SBP and DBP, PTH significant decreased, but the serum creatinine and urea nitrogen have no differences statistically. Conclusion Low protein diet and compound α-Ketoacid treatment probably helps to control patients＇ high blood pressure.

关 键 词：慢性 肾脏病(CKD) 高血压 低蛋白饮食 复方Α-酮酸 

分 类 号：R977.4[医药卫生—药品] R692.9[医药卫生—药学]